HomeIngredientPrebiotic Galacto-oligosaccharides and Fructo-oligosaccharides, but not Acacia Gum, Increase Iron Absorption from a Single High-dose Ferrous Fumarate Supplement in Iron-depleted Women

Prebiotic Galacto-oligosaccharides and Fructo-oligosaccharides, but not Acacia Gum, Increase Iron Absorption from a Single High-dose Ferrous Fumarate Supplement in Iron-depleted Women

January 23, 2022

J Nutr. 2022 Jan 7:nxac003. doi: 10.1093/jn/nxac003. Online ahead of print.

ABSTRACT

BACKGROUND: Prebiotic galacto-oligosaccharides (GOS) increase iron absorption from fortification-level iron doses given as ferrous fumarate (FeFum) in women and children. Whether GOS or other fibers, such as prebiotic fructo-oligosaccharides (FOS) and acacia gum, increase iron absorption from higher supplemental doses of FeFum is unclear.

OBJECTIVES: In iron-depleted [serum ferritin (SF)< 25μg/L] women, we tested if oral co-administration of 15g of GOS, FOS or acacia gum increases iron absorption from a 100mg iron supplement given as FeFum.

METHODS: In a randomized, single-blind cross-over study, 30 women (median age 26.2 years, median SF 12.9μg/L) consumed a 100mg iron tablet labelled with 4mg of 57Fe or 58Fe, given with either: a) 15g GOS; b) 15g FOS; c) 15g acacia gum; or d) 6.1g lactose and 1.5g sucrose (control; matching the amounts of sucrose and lactose present in the GOS powder providing 15 g GOS), dissolved in water. The primary outcome, fractional iron absorption (FIA), was assessed by erythrocyte isotopic incorporation 14 days after administration. Data were analysed using a linear mixed-effect model. We also tested, in vitro, iron solubility at different pH and dialyzability from the different supplement combinations administered in vivo.

RESULTS: FIA from FeFum given with GOS and FOS was significantly higher (+45% and 51%, respectively; P < 0.001 for both) compared with control; total iron absorption [median (IQR)] was 34.6 (28.4; 49.1); 36.1 (29.0; 46.2) and 23.9 (20.5; 34.0) mg, respectively. Acacia gum did not significantly affect FIA from FeFum (P = 0.688). In vitro, iron dialyzability of FeFum + GOS was 46% higher than of FeFum alone (P = 0.003).

CONCLUSIONS: In iron-depleted women, both GOS and FOS co-administration with FeFum increase iron absorption by ∼50% from a 100mg oral iron dose, resulting in an additional 10-12mg of absorbed iron. Thus, GOS and FOS may be promising new enhancers of supplemental iron absorption.The study was registered at clinicaltrials.gov as NCT04194255 (https://clinicaltrials.gov/ct2/show/NCT04194255).

PMID:35015879 | DOI:10.1093/jn/nxac003

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About The Author

Patrick Blanchard MD

Meet Dr. Blanchard Dr. Blanchard’s medical practice is an embodiment of Integrative health which brings conventional and complementary approaches together in a coordinated way. Conveniently located in sunny Florida and over the internet with ValiseMD’s secure HIPPA compliant telXmed servers. Since 1994, patients with a wide range of challenging medical problems have achieved optimum health using the best of natural medicine, judiciously combined with high-tech innovations. Breakthroughs are often achieved even after patients have consulted mainstream specialists and holistic practitioners. Dr. Blanchard is founder and CEO of ValiseMD, Inc. He is board certified in Family Medicine since 1994 and awarded Fellow of the American Academy of Family Physicians in 2001. He received the ‘Teacher of the Year’ award from the University of Kansas School of Medicine at completion of his residency in Family Medicine. He completed a fellowship at Wake Forest University in the field of vascular neurosonology. He holds a medical patent in the field of Gastroenterology. He holds an unrestricted license to practice medicine and surgery in Florida. He started his medical career as a Emergency Medical Technician, then as a Paramedic and later a Medical Doctor.