Cyanidin-3-O-glucoside supplementation ameliorates metabolic insulin resistance via restoration of nitric oxide-mediated endothelial insulin transport
Mol Nutr Food Res. 2021 Nov 28:e2100742. doi: 10.1002/mnfr.202100742. Online ahead of print. ABSTRACT SCOPE: Anthocyanin cyanidin-3-O-glucoside (Cy3G) has a great potential in prevention of...
SNHG12 regulates biological behaviors of ox-LDL-induced HA-VSMCs through upregulation of SPRY2 and NUB1
Atherosclerosis. 2021 Nov 8;340:1-11. doi: 10.1016/j.atherosclerosis.2021.11.006. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Human vascular smooth muscle cells (HA-VSMCs) are an important cell type...
Involvement of Gap Junctions in Acetylcholine-Induced Endothelium-Derived Hyperpolarization-Type Dilation of Retinal Arterioles in Rats
Biol Pharm Bull. 2021;44(12):1860-1865. doi: 10.1248/bpb.b21-00547. ABSTRACT An electrical communication between the endothelial and smooth muscle cells via gap junctions, which provides the signaling pathway...
The Anti-Inflammatory Effect of a Combination of Five Compounds From Five Chinese Herbal Medicines Used in the Treatment of COPD
Front Pharmacol. 2021 Oct 27;12:709702. doi: 10.3389/fphar.2021.709702. eCollection 2021. ABSTRACT Effective compound combination (ECC; i.e, 20-S-ginsenoside Rh1, astragaloside, icariin, nobiletin, and paeonol), derived from Chinese...
Effect of the icariin on endothelial microparticles, endothelial progenitor cells, platelets, and erectile function in spontaneously hypertensive rats
Andrology. 2021 Nov 14. doi: 10.1111/andr.13127. Online ahead of print. ABSTRACT OBJECTIVES: To investigate the effect of icariin on endothelial microparticles, endothelial progenitor cells, platelets,...
Screening and characterization of a GH78 alpha-l-rhamnosidase from Aspergillus terreus and its application in the bioconversion of icariin to icaritin with recombinant beta-glucosidase
Enzyme Microb Technol. 2021 Nov 10;153:109940. doi: 10.1016/j.enzmictec.2021.109940. Online ahead of print. ABSTRACT In this study, a GH78 α-L-rhamnosidase AtRha from Aspergillus terreus CCF3059 was...
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling
Int Immunopharmacol. 2021 Nov 17:108360. doi: 10.1016/j.intimp.2021.108360. Online ahead of print. ABSTRACT BACKGROUND AND PURPOSE: The M2 polarization of macrophages substantially contributes to the progression...
Icariin Alleviates Wear Particle-Induced Periprosthetic Osteolysis via Down-Regulation of the Estrogen Receptor alpha-mediated NF-kappaB Signaling Pathway in Macrophages
Front Pharmacol. 2021 Nov 3;12:746391. doi: 10.3389/fphar.2021.746391. eCollection 2021. ABSTRACT Periprosthetic osteolysis is one of the major long-term complications following total joint replacement. Its cause...
Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia-Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model
Biomedicines. 2021 Nov 19;9(11):1719. doi: 10.3390/biomedicines9111719. ABSTRACT Stroke, which is the second leading cause of mortality in the world, is urgently needed to explore the...
Icariin Protects H9c2 Rat Cardiomyoblasts from Doxorubicin-Induced Cardiotoxicity: Role of Caveolin-1 Upregulation and Enhanced Autophagic Response
Nutrients. 2021 Nov 14;13(11):4070. doi: 10.3390/nu13114070. ABSTRACT Doxorubicin (Doxo) is a widely used antineoplastic drug which often induces cardiomyopathy, leading to congestive heart failure through...
Icariin activates autophagy to trigger TGFbeta1 upregulation and promote angiogenesis in EA.hy926 human vascular endothelial cells
Bioengineered. 2021 Nov 30. doi: 10.1080/21655979.2021.2011637. Online ahead of print. ABSTRACT Angiogenesis plays an important role in tissue development and repair, and how to regulate...
3D printing of alginate dialdehyde-gelatin (ADA-GEL) hydrogels incorporating phytotherapeutic icariin loaded mesoporous SiO(2)-CaO nanoparticles for bone tissue engineering
Mater Sci Eng C Mater Biol Appl. 2021 Dec;131:112470. doi: 10.1016/j.msec.2021.112470. Epub 2021 Oct 2. ABSTRACT 3D printing enables a better control over the microstructure...
Icariin accelerates cartilage defect repair by promoting chondrogenic differentiation of BMSCs under conditions of oxygen-glucose deprivation
J Cell Mol Med. 2021 Dec 3. doi: 10.1111/jcmm.17073. Online ahead of print. ABSTRACT This study explored the role played by combined ICA and bone...
Doctor, Do You Know Red Yeast Rice?
Praxis (Bern 1994). 2021;110(4):207-220. doi: 10.1024/1661-8157/a003617. ABSTRACT Doctor, Do You Know Red Yeast Rice? Abstract. We present cases of patients with high total cholesterol who...
Hypolipaemic nutraceutics: red yeast rice and Armolipid, berberine and bergamot
Ann Agric Environ Med. 2021 Mar 18;28(1):81-88. doi: 10.26444/aaem/130629. Epub 2020 Dec 2. ABSTRACT INTRODUCTION: Increased serum cholesterol levels constitute one of the main risk...