Classical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation
Sci Rep. 2024 Mar 9;14(1):5782. doi: 10.1038/s41598-024-56220-0. ABSTRACT To test the hypothesis that genetic and pharmacological modulation of the classical cannabinoid type 1 (CB1) and...
Prenatal delta-9-tetrahydrocannabinol exposure alters fetal neurodevelopment in rhesus macaques
Sci Rep. 2024 Mar 9;14(1):5808. doi: 10.1038/s41598-024-56386-7. ABSTRACT Prenatal cannabis use is associated with adverse offspring neurodevelopmental outcomes, however the underlying mechanisms are relatively unknown....
5-HT(2A) receptors are involved in the pharmaco-toxicological effects of the synthetic cannabinoids JWH-018 and 5F-PB22: In vivo studies in mice
Eur J Pharmacol. 2024 Mar 6:176486. doi: 10.1016/j.ejphar.2024.176486. Online ahead of print. ABSTRACT Over the last years, Synthetic Cannabinoids (SCs) have been among the largest...
Protective effect of phenylpropionamides in the seed of Cannabis Sativa L. on Parkinson’s disease through autophagy
Fitoterapia. 2024 Mar 6:105883. doi: 10.1016/j.fitote.2024.105883. Online ahead of print. ABSTRACT Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world. As...
Discovery of Latent Cannabichromene Cyclase Activity in Marine Bacterial Flavoenzymes
ACS Synth Biol. 2024 Mar 8. doi: 10.1021/acssynbio.4c00051. Online ahead of print. ABSTRACT Production of phytocannabinoids remains an area of active scientific interest due to...
First Report of Lingonberry Stunted Yellows Disease of Vaccinium vitis-idaea L. associated with ‘Candidatus Phytoplasma trifolii’-Related Phytoplasma Strain in Lithuania
Plant Dis. 2024 Mar 8. doi: 10.1094/PDIS-02-24-0284-PDN. Online ahead of print. ABSTRACT Lingonberries (Vaccinium vitis-idaea L.) are low-growing, evergreen shrubs of cooler, northern regions of...
Cannabinoids in the treatment of glioblastoma
Pharmacol Rep. 2024 Mar 8. doi: 10.1007/s43440-024-00580-x. Online ahead of print. ABSTRACT Glioblastoma (GBM) is the most prevalent primary malignant tumor of the nervous system....
In vitro ruminal fermentation, core nutrient, fatty acids and mineral matter of pennyroyal (Mentha pulegium L.) herbage at different phenological stages
Vet Med Sci. 2024 Mar;10(2):e1397. doi: 10.1002/vms3.1397. ABSTRACT BACKGROUND: In ruminants, fibrous feedstuffs must be included in the ration to ensure normal rumen physiology and...
Moringa oleifera leaves ethanolic extract counteracts cortical neurodegeneration induced by aluminum chloride in rats
Toxicol Res (Camb). 2024 Mar 5;13(2):tfae028. doi: 10.1093/toxres/tfae028. eCollection 2024 Apr. ABSTRACT BACKGROUND: Aluminum, a well-recognized neurotoxin, is implicated in various neurodegenerative disorders. Moringa oleifera...
Characterizing Cannabis Use and Perceived Benefit in a Tertiary Headache Center Patient Sample
Neurol Clin Pract. 2024 Apr;14(2):e200285. doi: 10.1212/CPJ.0000000000200285. Epub 2024 Mar 6. ABSTRACT BACKGROUND AND OBJECTIVES: Research suggests a potential role for cannabinoids in the etiology...
Psychedelic substitution: altered substance use patterns following psychedelic use in a global survey
Front Psychiatry. 2024 Feb 22;15:1349565. doi: 10.3389/fpsyt.2024.1349565. eCollection 2024. ABSTRACT INTRODUCTION: Recent research suggests that psychedelics may have potential for the treatment of various substance...
NPS-EQA PART I: Four years’ experience in external quality assessment program in Italy for classical and new psychoactive substances analysis in oral fluid
J Pharm Biomed Anal. 2024 Mar 2;243:116084. doi: 10.1016/j.jpba.2024.116084. Online ahead of print. ABSTRACT In 2019, Italian National Institute of Health established an external quality...
Dual effect of anandamide on spinal nociceptive transmission in control and inflammatory conditions
Biomed Pharmacother. 2024 Mar 6;173:116369. doi: 10.1016/j.biopha.2024.116369. Online ahead of print. ABSTRACT Anandamide (AEA) is an important modulator of nociception in the spinal dorsal horn,...
Chronic high-dose dimenhydrinate use contributing to early multifactorial cognitive impairment
BMJ Case Rep. 2024 Mar 7;17(3):e258493. doi: 10.1136/bcr-2023-258493. ABSTRACT Dimenhydrinate is an over-the-counter antihistaminergic medication with anticholinergic properties used to treat nausea or motion sickness...
Prior acute exercise restores postprandial fat oxidation in active cannabis users
Physiol Rep. 2024 Mar;12(5):e15968. doi: 10.14814/phy2.15968. ABSTRACT Data suggest cannabis users have similar or lower levels of blood lipids compared to nonusers. However, the extent...