Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy
bioRxiv [Preprint]. 2024 Mar 23:2023.08.25.554814. doi: 10.1101/2023.08.25.554814. ABSTRACT Research into the disequilibrium of microglial phenotypes has become an area of intense focus in neurodegenerative disease...
Cannabinoid Receptor Signaling is Dependent on Sub-Cellular Location
bioRxiv [Preprint]. 2024 Mar 22:2024.03.21.586146. doi: 10.1101/2024.03.21.586146. ABSTRACT G protein-coupled receptors (GPCRs) are membrane bound signaling molecules that regulate many aspects of human physiology. Recent...
Pharmacological evaluation of new generation OXIZID synthetic cannabinoid receptor agonists
Eur J Pharmacol. 2024 Mar 30:176549. doi: 10.1016/j.ejphar.2024.176549. Online ahead of print. ABSTRACT Synthetic cannabinoid receptor agonists (SCRAs) remain one the largest classes of new...
Pharmacodynamic effects following co-administration of cannabinoids and opioids: A scoping review of human experimental studies
Pain Med. 2024 Apr 1:pnae024. doi: 10.1093/pm/pnae024. Online ahead of print. ABSTRACT BACKGROUND: Cannabinoids are increasingly used in the management of chronic pain. Although analgesic...
Substance use and spine density: a systematic review and meta-analysis of preclinical studies
Mol Psychiatry. 2024 Apr 2. doi: 10.1038/s41380-024-02519-3. Online ahead of print. ABSTRACT The elucidation of synaptic density changes provides valuable insights into the underlying brain...
Pharmacological evaluation of new generation OXIZID synthetic cannabinoid receptor agonists
Eur J Pharmacol. 2024 Mar 30:176549. doi: 10.1016/j.ejphar.2024.176549. Online ahead of print. ABSTRACT Synthetic cannabinoid receptor agonists (SCRAs) remain one the largest classes of new...
A proof-of-concept study testing the factor structure of the Stop Signal Task: overlap with substance use and mental health symptoms
Am J Drug Alcohol Abuse. 2024 Apr 1:1-9. doi: 10.1080/00952990.2024.2316599. Online ahead of print. ABSTRACT Background: Research utilizing experimental tasks usually does not report estimates...
Assessing Risk Factors and Comorbidities in the Treatment of Chronic Pain: A Narrative Review
Curr Pain Headache Rep. 2024 Apr 1. doi: 10.1007/s11916-024-01249-z. Online ahead of print. ABSTRACT PURPOSE OF REVIEW: Chronic pain affects a significant portion of the...
CB (1) Cannabinoid Receptor Agonists Induce Acute Respiratory Depression in Awake Mice
bioRxiv [Preprint]. 2024 Mar 13:2024.03.12.584260. doi: 10.1101/2024.03.12.584260. ABSTRACT Recreational use of synthetic cannabinoid agonists (i.e., “Spice” compounds) that target the Cannabinoid Type 1 receptor (CB...
Acute paraquat poisoning in an adolescent with compromised outcome: A case report
SAGE Open Med Case Rep. 2024 Mar 28;12:2050313X241240098. doi: 10.1177/2050313X241240098. eCollection 2024. ABSTRACT Paraquat, a highly toxic herbicide, accounts for a substantial number of poisoning-related...
Effect of saline irrigation and plant-based biostimulant application on fiber hemp (Cannabis sativa L.) growth and phytocannabinoid composition
Front Plant Sci. 2024 Mar 15;15:1293184. doi: 10.3389/fpls.2024.1293184. eCollection 2024. ABSTRACT Phytocannabinoids represent the hallmark of the secondary metabolism of Cannabis sativa. The content of...
CB 1 Cannabinoid Receptor Agonists Induce Acute Respiratory Depression in Awake Mice
bioRxiv [Preprint]. 2024 Mar 13:2024.03.12.584260. doi: 10.1101/2024.03.12.584260. ABSTRACT Recreational use of synthetic cannabinoid agonists (i.e., “Spice” compounds) that target the Cannabinoid Type 1 receptor (CB...
Effect of saline irrigation and plant-based biostimulant application on fiber hemp (Cannabis sativa L.) growth and phytocannabinoid composition
Front Plant Sci. 2024 Mar 15;15:1293184. doi: 10.3389/fpls.2024.1293184. eCollection 2024. ABSTRACT Phytocannabinoids represent the hallmark of the secondary metabolism of Cannabis sativa. The content of...
Gapless assembly of complete human and plant chromosomes using only nanopore sequencing
bioRxiv [Preprint]. 2024 Mar 19:2024.03.15.585294. doi: 10.1101/2024.03.15.585294. ABSTRACT The combination of ultra-long Oxford Nanopore (ONT) sequencing reads with long, accurate PacBio HiFi reads has enabled...
Developing carotenoids-enhanced tomato fruit with multi-transgene stacking strategies
Plant Physiol Biochem. 2024 Mar 28;210:108575. doi: 10.1016/j.plaphy.2024.108575. Online ahead of print. ABSTRACT As natural dominant pigments, carotenoids and their derivatives not only contribute to...