Diet suppresses glioblastoma initiation in mice by maintaining quiescence of mutation-bearing neural stem cells
Dev Cell. 2023 Apr 17:S1534-5807(23)00148-X. doi: 10.1016/j.devcel.2023.03.021. Online ahead of print. ABSTRACT Glioblastoma is thought to originate from neural stem cells (NSCs) of the subventricular...
SELECTED CANNABIS TERPENES SYNERGIZE WITH THC TO PRODUCE INCREASED CB1 RECEPTOR ACTIVATION
Biochem Pharmacol. 2023 Apr 19:115548. doi: 10.1016/j.bcp.2023.115548. Online ahead of print. ABSTRACT The cannabis plant exerts its pharmaceutical activity primarily by the binding of cannabinoids...
Cannabidiol regulates behavioral and brain alterations induced by spontaneous alcohol withdrawal
Neuropharmacology. 2023 Apr 19:109549. doi: 10.1016/j.neuropharm.2023.109549. Online ahead of print. ABSTRACT The main goal of this study was to evaluate if the administration of cannabidiol...
RAMP and MRAP Accessory Proteins have Selective Effects on Expression and Signalling of the CB1, CB2, GPR18 and GPR55 Cannabinoid Receptors
Br J Pharmacol. 2023 Apr 21. doi: 10.1111/bph.16095. Online ahead of print. ABSTRACT BACKGROUND AND PURPOSE: Receptor activity-modifying proteins (RAMPs) and melanocortin receptor accessory proteins...
Control of a hippocampal recurrent excitatory circuit by cannabinoid receptor-interacting protein Gap43
Nat Commun. 2023 Apr 21;14(1):2303. doi: 10.1038/s41467-023-38026-2. ABSTRACT The type-1 cannabinoid receptor (CB1R) is widely expressed in excitatory and inhibitory nerve terminals, and by suppressing...
Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model
J Headache Pain. 2023 Apr 21;24(1):44. doi: 10.1186/s10194-023-01580-7. ABSTRACT BACKGROUND: Central sensitization has been widely accepted as an underlying pathophysiological mechanism of chronic migraine (CM),...
Substance abuse and male sexual dysfunction: what lies beneath?
Sex Med Rev. 2023 Apr 21:qead011. doi: 10.1093/sxmrev/qead011. Online ahead of print. ABSTRACT INTRODUCTION: Substance abuse has become a worldwide health problem, leading to numerous...
Ingestion of Illicit Substances by Young Children Before and During the COVID-19 Pandemic
JAMA Netw Open. 2023 Apr 3;6(4):e239549. doi: 10.1001/jamanetworkopen.2023.9549. ABSTRACT IMPORTANCE: Information about the trend in illicit substance ingestions among young children during the pandemic is...
In Memoriam of Professor Mary E. Abood
Cannabis Cannabinoid Res. 2023 Apr 19. doi: 10.1089/can.2023.0043. Online ahead of print. NO ABSTRACT PMID:37083481 | DOI:10.1089/can.2023.0043...
Δ9-THC and CBD in Plasma, Oral Fluid, Exhaled Breath, and Urine from 23 Patients Administered Sativex
Cannabis Cannabinoid Res. 2023 Apr 19. doi: 10.1089/can.2022.0179. Online ahead of print. ABSTRACT Background: Detecting the presence of Δ9-THC and CBD is mainly done through...
The Use of Traditional, Complementary, and Integrative Medicine in Cancer: Data-Mining Study of 1 Million Web-Based Posts From Health Forums and Social Media Platforms
J Med Internet Res. 2023 Apr 21;25:e45408. doi: 10.2196/45408. ABSTRACT BACKGROUND: Patients with cancer are increasingly using forums and social media platforms to access health...
Effects of cannabis on in-patient diabetic patients with prior revascularized (PCI and/or CABG) myocardial infarction and health care service utilization
Ann Transl Med. 2023 Mar 31;11(6):276. doi: 10.21037/atm-22-4040. Epub 2023 Mar 21. NO ABSTRACT PMID:37082663 | PMC:PMC10113086 | DOI:10.21037/atm-22-4040...
Nutritional and immunological evaluation of Nannochloropsis oculata as a potential Nile tilapia-aquafeed supplement
BMC Vet Res. 2023 Apr 19;19(1):65. doi: 10.1186/s12917-023-03618-z. ABSTRACT Nannochloropsis oculata (N. oculata) is a marine microalga containing bioactive compounds and a high omega-3 polyunsaturated...
MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy
Front Physiol. 2023 Apr 4;14:1086243. doi: 10.3389/fphys.2023.1086243. eCollection 2023. ABSTRACT Background: T-type Ca2+ channels (Cav3) represent emerging therapeutic targets for a range of neurological disorders,...
Psychosocial Correlates of Opioid Use Profiles among Young Adults in a Longitudinal Study across 6 US Metropolitan Areas
Subst Use Misuse. 2023 Apr 20:1-8. doi: 10.1080/10826084.2023.2201839. Online ahead of print. ABSTRACT Background: Examining opioid use profiles over time and related factors among young...