Overexpression of cannabinoid receptor 2 is associated with human breast cancer proliferation, apoptosis, chemosensitivity and prognosis via the PI3K/Akt/mTOR signaling pathway
Cancer Med. 2023 May 23. doi: 10.1002/cam4.6037. Online ahead of print. ABSTRACT INTRODUCTION: The cannabinoid receptor 2 (CB2) is mainly involved in the immune system....
Cannabidiol Protects Dopaminergic-like Neurons against Paraquat- and Maneb-Induced Cell Death through Safeguarding DJ-1CYS106 and Caspase 3 Independently of Cannabinoid Receptors: Relevance in Parkinson’s Disease
ACS Chem Neurosci. 2023 May 23. doi: 10.1021/acschemneuro.3c00176. Online ahead of print. ABSTRACT Parkinson’s disease (PD), a progressive neurodegenerative movement disorder, has reached pandemic status...
Drivers of Purchase Decisions Among Consumers of Dried Flower Cannabis Products – A Discrete Choice Experiment
J Stud Alcohol Drugs. 2023 May 18. doi: 10.15288/jsad.22-00269. Online ahead of print. ABSTRACT BACKGROUND: Cannabis was legalized for non-medical use in Canada in 2018....
Adolescents’ views on preventing youth cannabis marketing exposure: A concept mapping approach
J Stud Alcohol Drugs. 2023 May 18. doi: 10.15288/jsad.22-00299. Online ahead of print. ABSTRACT OBJECTIVE: The increasing number of states legalizing recreational cannabis use have...
Clinical effectiveness of nirmatrelvir plus ritonavir in patients with COVID-19 and substance use disorders based on real-world data
J Med Virol. 2023 May;95(5):e28801. doi: 10.1002/jmv.28801. ABSTRACT This study assessed the clinical efficacy of nirmatrelvir plus ritonavir (NMV-r) in treating patients with coronavirus disease-2019...
Integrative medicine, naturopathic and complementary medicine in the treatment of fibromyalgia syndrome : An overview against the background of clinical experiences from routine treatment
Schmerz. 2023 May 22. doi: 10.1007/s00482-023-00716-7. Online ahead of print. ABSTRACT Fibromyalgia syndrome is classified as a functional somatic syndrome. There are typical but not...
Self-reported adverse events associated with ∆8-Tetrahydrocannabinol (Delta-8-THC) Use
J Cannabis Res. 2023 May 23;5(1):15. doi: 10.1186/s42238-023-00191-y. ABSTRACT BACKGROUND: There is an expanding unregulated market for a psychotropic compound called ∆8-Tetrahydrocannabinol (delta-8-THC) that is...
Effect of N-oleoyl dopamine on myofibroblast trans-differentiation of retinal pigment epithelial cells
Biochem Biophys Res Commun. 2023 May 14;667:127-131. doi: 10.1016/j.bbrc.2023.05.040. Online ahead of print. ABSTRACT Retinal pigment epithelial (RPE) cells contribute to several clinical conditions resulting...
Medicinal cannabis products for the treatment of acute pain
World J Clin Cases. 2023 Apr 26;11(12):2670-2676. doi: 10.12998/wjcc.v11.i12.2670. ABSTRACT For thousands of years, medicinal cannabis has been used for pain treatment, but its use...
Is Medical Cannabis Evidence-Based Medicine? Concerns Based on Qualifying Conditions and the National Academy of Sciences Report
medRxiv. 2023 May 10:2023.05.01.23289286. doi: 10.1101/2023.05.01.23289286. Preprint. ABSTRACT This study aims to examine the coherence of state-level qualifying conditions (QCs) for medical cannabis (MC) with...
Cannabis sativa L. modulates altered metabolic pathways involved in key metabolisms in human breast cancer (MCF-7) cells: A metabolomics study
Heliyon. 2023 May 9;9(5):e16156. doi: 10.1016/j.heliyon.2023.e16156. eCollection 2023 May. ABSTRACT The present study investigated the ability of Cannabis sativa leaves infusion (CSI) to modulate major...
Hair endocannabinoids predict physiological fear conditioning and salivary endocannabinoids predict subjective stress reactivity in humans
Psychoneuroendocrinology. 2023 May 18;154:106296. doi: 10.1016/j.psyneuen.2023.106296. Online ahead of print. ABSTRACT On the basis of substantial preclinical evidence, the endogenous cannabinoid system has been proposed...
Cognitive Safety Data from a Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Phase IIb Study of the Effects of a Cannabidiol and Δ9-Tetrahydrocannabinol Drug on Parkinson’s Disease-Related Motor Symptoms
Mov Disord. 2023 May 22. doi: 10.1002/mds.29447. Online ahead of print. ABSTRACT BACKGROUND: Cannabis is increasingly available worldwide but its impact on cognition in Parkinson’s...
Assessment of Screening Tools to Identify Substance Use Disorders Among Adolescents
JAMA Netw Open. 2023 May 1;6(5):e2314422. doi: 10.1001/jamanetworkopen.2023.14422. ABSTRACT IMPORTANCE: Efficient screening tools that effectively identify substance use disorders (SUDs) among youths are needed. OBJECTIVE:...
Primary care provider attitudes, experiences and practices about cannabidiol (CBD) and barriers to patient-provider communication about CBD use: A qualitative study
PEC Innov. 2022 Apr 28;1:100044. doi: 10.1016/j.pecinn.2022.100044. eCollection 2022 Dec. ABSTRACT OBJECTIVES: Federal hemp legalization and ongoing shifts in US marijuana laws have led to...