A kinetic model for positive allosteric modulator (PAM)-antagonists for the type 1 cannabinoid receptor (CB1 )
Br J Pharmacol. 2023 Jun 5. doi: 10.1111/bph.16158. Online ahead of print. ABSTRACT BACKGROUND AND PURPOSE: The type 1 cannabinoid receptor (CB1 ) is amongst...
Oral CBD-rich hemp extract modulates sterile inflammation in female and male rats
Front Physiol. 2023 May 18;14:1112906. doi: 10.3389/fphys.2023.1112906. eCollection 2023. ABSTRACT Introduction: Cannabidiol (CBD) extract from the cannabis plant has biomedical and nutraceutical potential. Unlike tetrahydrocannabinol...
Sub-optimal nutrient regime coupled with Bacillus and Pseudomonas sp. inoculation influences trichome density and cannabinoid profiles in drug-type Cannabis sativa
Front Plant Sci. 2023 May 19;14:1131346. doi: 10.3389/fpls.2023.1131346. eCollection 2023. ABSTRACT Cannabis sativa remains under heavy legal restriction around the globe that prevents extensive investigations...
Fatty acid composition on diet and carcasses, growth, body indices and profile serum of Asian redtail catfish ( Hemibagrus nemurus) fed a diet containing different levels of EPA and DHA
F1000Res. 2023 May 15;11:1409. doi: 10.12688/f1000research.126487.2. eCollection 2022. ABSTRACT Background: The Asian redtail catfish Hemibagrus nemurus is a promising commercial aquaculture freshwater big-sized Bagridae catfish...
Acute cannabidiol treatment enhances social interaction in adult male mice
Adv Drug Alcohol Res. 2023;3:11163. doi: 10.3389/adar.2023.11163. Epub 2023 May 10. ABSTRACT Cannabidiol (CBD) is a non-intoxicating phytochemical from Cannabis sativa that is increasingly used...
An Unnamed Human Oral Bergeyella sp. as the Cause of an Unusual Bacterial Keratitis
Case Rep Ophthalmol Med. 2023 May 25;2023:3288984. doi: 10.1155/2023/3288984. eCollection 2023. ABSTRACT Purpose. We report a case of bacterial keratitis secondary to an undescribed Bergeyella...
Non-medical prescription opioid use among high school students in 38 U.S. States
Addict Behav Rep. 2023 May 25;17:100498. doi: 10.1016/j.abrep.2023.100498. eCollection 2023 Jun. ABSTRACT BACKGROUND: Lifetime prevalence of non-medical prescription opioid use (NMPOU) among adolescents exceeds 10%....
Targeted metabolomics unravels altered phenylalanine levels in piglets receiving total parenteral nutrition
FASEB J. 2023 Jul;37(7):e23014. doi: 10.1096/fj.202300261RR. ABSTRACT Parenteral nutrition, received by many patients with intestinal failure, can induce hepatobiliary complications, which is termed as parenteral...
Accurately classifying cannabis blunt use as tobacco-cannabis co-use versus exclusive cannabis use
Drug Alcohol Depend. 2023 May 21;249:109941. doi: 10.1016/j.drugalcdep.2023.109941. Online ahead of print. ABSTRACT BACKGROUND: Historically, blunt use constituted tobacco-cannabis co-use based on the products available...
The association of alcohol dependence and consumption during adolescence with depression in young adulthood, in England: a prospective cohort study
Lancet Psychiatry. 2023 Jun 1:S2215-0366(23)00138-4. doi: 10.1016/S2215-0366(23)00138-4. Online ahead of print. ABSTRACT BACKGROUND: The role of alcohol use in the development of depression is unclear....
Does drug use affect the efficacy of amisulpride, aripiprazole and olanzapine in patients with schizophrenia spectrum disorders? Results from a pragmatic, randomised study
Gen Hosp Psychiatry. 2023 May 8;83:185-193. doi: 10.1016/j.genhosppsych.2023.05.003. Online ahead of print. ABSTRACT OBJECTIVES: Drug use is prevalent in patients with schizophrenia spectrum disorders (SSD)...
A systematic review and meta-analysis of the association between young adults’ sleep habits and substance use, with a focus on self-medication behaviours
Sleep Med Rev. 2023 May 22;70:101792. doi: 10.1016/j.smrv.2023.101792. Online ahead of print. ABSTRACT Young adults (18-30 years) are vulnerable to sleep-wake disturbances and substance use,...
Chronic Δ9-tetrahydrocannabinol treatment has dose-dependent effects on open field exploratory behavior and [3H] SR141716A receptor binding in the rat brain
Life Sci. 2023 Jun 1:121825. doi: 10.1016/j.lfs.2023.121825. Online ahead of print. ABSTRACT AIMS: Acute and chronic Δ9-THC exposure paradigms affect the body differently. More must...
Climate change will cause climatic niche contraction of Vaccinium myrtillus L. and V. vitis-idaea L. in Europe
Sci Total Environ. 2023 May 31:164483. doi: 10.1016/j.scitotenv.2023.164483. Online ahead of print. ABSTRACT We estimated climate niche shifts and threat levels under various climate change...
Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood
Cell Metab. 2023 May 24:S1550-4131(23)00179-1. doi: 10.1016/j.cmet.2023.05.002. Online ahead of print. ABSTRACT One of cannabis’ most iconic effects is the stimulation of hedonic high-calorie eating-the...