Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor
Molecules. 2023 Jun 24;28(13):4958. doi: 10.3390/molecules28134958. ABSTRACT Selective ligands of the CB2 receptor are receiving considerable attention due to their potential as therapeutic agents for...
Understanding the Mechanisms of Action and Effects of Drugs of Abuse
Molecules. 2023 Jun 24;28(13):4969. doi: 10.3390/molecules28134969. ABSTRACT AIM: Drug abuse and addiction are major public health concerns, with millions of people worldwide affected by the...
The Anti-Inflammatory Effects of Cannabis sativa Extracts on LPS-Induced Cytokines Release in Human Macrophages
Molecules. 2023 Jun 25;28(13):4991. doi: 10.3390/molecules28134991. ABSTRACT Inflammation is the response of the innate immune system to any type of injury. Although acute inflammation is...
Biochemical Changes Induced by the Administration of Cannabis sativa Seeds in Diabetic Wistar Rats
Nutrients. 2023 Jun 28;15(13):2944. doi: 10.3390/nu15132944. ABSTRACT The present pilot study investigates the blood biochemical changes induced by hemp seeds in rats with diabetes. The...
Prevention of Taste Alterations in Patients with Cancer Receiving Paclitaxel- or Oxaliplatin-Based Chemotherapy-A Pilot Trial of Cannabidiol
Nutrients. 2023 Jul 1;15(13):3014. doi: 10.3390/nu15133014. ABSTRACT INTRODUCTION: Taste alteration is a common adverse effect of chemotherapy. This study aimed to investigate the effect of...
Intracranial Hemorrhage Secondary to Vaping: A Case Report and Literature Review
Cureus. 2023 Jun 12;15(6):e40288. doi: 10.7759/cureus.40288. eCollection 2023 Jun. ABSTRACT Vaping and marijuana use are becoming more common and accessible in young adults. However, questions...
Should gastroenterologists prescribe cannabis? The highs, the lows and the unknowns
World J Clin Cases. 2023 Jun 26;11(18):4210-4230. doi: 10.12998/wjcc.v11.i18.4210. ABSTRACT Cannabis, commonly known as marijuana, is a drug extracted from the Cannabis plant known for...
Trends in Cannabis and Alcohol Use by Sexual Identity in the 2015-2019 National Survey on Drug Use and Health
J Stud Alcohol Drugs. 2023 Jul 7. doi: 10.15288/jsad.22-00410. Online ahead of print. ABSTRACT PURPOSE: Sexual minority individuals are at substantially elevated risk for both...
Cannabinoid receptor 2 (CB2) agonists and L-arginine ameliorate diabetic nephropathy in rats by suppressing inflammation and fibrosis through NF-κβ pathway
Naunyn Schmiedebergs Arch Pharmacol. 2023 Jul 14. doi: 10.1007/s00210-023-02597-0. Online ahead of print. ABSTRACT Diabetic nephropathy (DN) is a condition that leads to end-stage chronic...
Motifs in Natural Products as Useful Scaffolds to Obtain Novel Benzo[d]imidazole-Based Cannabinoid Type 2 (CB2) Receptor Agonists
Int J Mol Sci. 2023 Jun 30;24(13):10918. doi: 10.3390/ijms241310918. ABSTRACT The endocannabinoid system (ECS) constitutes a broad-spectrum modulator of homeostasis in mammals, providing therapeutic opportunities...
Eco-friendly TEMPO/laccase/O2 biocatalytic system for degradation of Indigo Carmine: operative conditions and laccase inactivation
RSC Adv. 2023 Jul 11;13(30):20737-20747. doi: 10.1039/d3ra03107a. eCollection 2023 Jul 7. ABSTRACT The biocatalytic system laccase/TEMPO/O2 has attracted the attention of researchers over the past...
Cannabis use is associated with decreased opioid prescription fulfillment following single level anterior cervical discectomy and fusion (ACDF)
N Am Spine Soc J. 2023 May 3;14:100226. doi: 10.1016/j.xnsj.2023.100226. eCollection 2023 Jun. ABSTRACT BACKGROUND: Recently, there has been increasing legalization of marijuana within the...
Cannabis: Drug of Abuse and Therapeutic Agent, Two Sides of the Same Coin
Rev Invest Clin. 2023;75(3):105-128. doi: 10.24875/RIC.23000112. ABSTRACT The consumption of Cannabis sativa plant, known as marijuana in the Western world, for different purposes (therapeutic, intoxicating,...
Cannabis: Drug of Abuse and Therapeutic Agent, Two Sides of the Same Coin
Rev Invest Clin. 2023;75(3):105-128. doi: 10.24875/RIC.23000112. ABSTRACT The consumption of Cannabis sativa plant, known as marijuana in the Western world, for different purposes (therapeutic, intoxicating,...
Interactive effect of adverse child experiences and suicidal thoughts and behaviors on adolescent alcohol and cannabis use frequency
Psychol Addict Behav. 2023 Jul 13. doi: 10.1037/adb0000947. Online ahead of print. ABSTRACT OBJECTIVE: Adolescents with adverse childhood experiences (ACEs) and suicidality may engage in...