Effect of vitamin D3 on mild cognitive impairment in type 2 diabetic mice and its possible mechanism
Beijing Da Xue Xue Bao Yi Xue Ban. 2023 Aug 18;55(4):587-592. ABSTRACT OBJECTIVE: To investigate the effect of vitamin D3 on mild cognitive impairment in...
Phenytoin’s Pharmacological Interactions with Medicinal Herbs: A Review
Pharmazie. 2023 Jul 1;78(6):77-81. doi: 10.1691/ph.2023.3546. ABSTRACT Physiologic changes due to aging, pregnancy, nutritional status, drug interactions, and can affect pharmacokinetics and pharmacodynamics of antiepileptic...
Medical Cannabis Received by Patients According to Qualifying Condition in a US State Cannabis Program: Product Choice, Dosing, and Age-Related Trends
Curr Ther Res Clin Exp. 2023 Jun 11;99:100709. doi: 10.1016/j.curtheres.2023.100709. eCollection 2023. ABSTRACT BACKGROUND: Little is known about the distribution of cannabidiol (CBD) and Δ9-tetrahydrocannabinol...
Cannabis Use Is Associated With Depression Severity and Suicidality in the National Comorbidity Survey-Adolescent Supplement
JAACAP Open. 2023 Jun;1(1):24-35. doi: 10.1016/j.jaacop.2023.02.002. Epub 2023 Mar 3. ABSTRACT OBJECTIVE: To investigate the association of cannabis use with major depression and suicidal behavior...
Prevention and Intervention with Young People as a Critical Public Health Strategy to Curtail the Opioid Epidemic: A Call to Action
J Addict Res Ther. 2023;14(4):521. Epub 2023 Apr 27. ABSTRACT Opioid use continues to represent a significant public health problem in the United States, as...
Anandamide reduces the migration of lymphocytes to the intestine BY CB2 activation and reduces TNF-α in the target organs, protecting mice from graft-versus-host disease
Eur J Pharmacol. 2023 Aug 1:175932. doi: 10.1016/j.ejphar.2023.175932. Online ahead of print. ABSTRACT Graft-versus-host disease (GVHD) is a serious inflammatory illness that often occurs as...
Does the “Entourage Effect” in Cannabinoids Exist? A Narrative Scoping Review
Cannabis Cannabinoid Res. 2023 Aug 3. doi: 10.1089/can.2023.0052. Online ahead of print. ABSTRACT Background: The concept of an “entourage” effect in the cannabis and cannabinoids’...
Does the “Entourage Effect” in Cannabinoids Exist? A Narrative Scoping Review
Cannabis Cannabinoid Res. 2023 Aug 3. doi: 10.1089/can.2023.0052. Online ahead of print. ABSTRACT Background: The concept of an “entourage” effect in the cannabis and cannabinoids’...
Biobehavioral Interactions between Endocannabinoid and Hypothalamic-pituitary-adrenal Systems in Psychosis: A Systematic Review
Curr Neuropharmacol. 2023 Aug 1. doi: 10.2174/1570159X21666230801150032. Online ahead of print. ABSTRACT BACKGROUND: The diathesis-stress paradigm and the cannabinoid-hypothesis have been proposed as possible pathophysiological...
Hippocampal differential expression underlying the neuroprotective effect of delta-9-tetrahydrocannabinol microdose on old mice
Front Neurosci. 2023 Jul 18;17:1182932. doi: 10.3389/fnins.2023.1182932. eCollection 2023. ABSTRACT Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound of the cannabis plant and an exogenous ligand...
Cannabinoid receptor type 1 (CB1R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3
iScience. 2023 Jun 25;26(7):107207. doi: 10.1016/j.isci.2023.107207. eCollection 2023 Jul 21. ABSTRACT Molecular interactions between anorexigenic leptin and orexigenic endocannabinoids, although of great metabolic significance, are...
Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin
Nat Commun. 2023 Aug 2;14(1):4630. doi: 10.1038/s41467-023-40362-2. ABSTRACT The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in human cancers. Despite increasing interest...
Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin
Nat Commun. 2023 Aug 2;14(1):4630. doi: 10.1038/s41467-023-40362-2. ABSTRACT The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in human cancers. Despite increasing interest...
Injunctive Norms and Driving Under the Influence and Riding With an Impaired Driver Among Young Adults in Washington State
J Adolesc Health. 2023 Aug 2:S1054-139X(23)00320-8. doi: 10.1016/j.jadohealth.2023.06.010. Online ahead of print. ABSTRACT PURPOSE: Alcohol- and cannabis-impaired driving behaviors remain a public health concern especially...
Evaluation of Field Sobriety Tests for Identifying Drivers Under the Influence of Cannabis: A Randomized Clinical Trial
JAMA Psychiatry. 2023 Aug 2. doi: 10.1001/jamapsychiatry.2023.2345. Online ahead of print. ABSTRACT IMPORTANCE: With increasing medicinal and recreational cannabis legalization, there is a public health...