HomeIngredientEugenol Elicits Prolongevity by Increasing Resistance to Oxidative Stress in C. elegans

Eugenol Elicits Prolongevity by Increasing Resistance to Oxidative Stress in C. elegans

March 28, 2022

CNS Neurol Disord Drug Targets. 2021 Oct 8. doi: 10.2174/1871527320666211008150347. Online ahead of print.

ABSTRACT

AIM: To analyze the efficacy of eugenol on longevity by assessing its antioxidant effect using Caenorhabditis elegans as an animal model.

BACKGROUND: Eugenol is a major polyphenolic component of Ocimum sanctum (Tulsi) which attributes wide pharmacological activities and can serve as a biomarker. However, the possible effect of eugenol on longevity in Caenorhabditis elegans has not been reported.

OBJECTIVE: The objective of this investigation was to provide first scientific based results about effect of eugenol on longevity, slowing down of paralysis in Alzheimer’s model and mechanism behind it in Caenorhabditis elegans animal model system.

METHODS: The phenolic components of methanolic extract of Ocimum sanctum were analyzed by RP- HPLC. Worms were exposed to different concentrations of extract and one of its components -eugenol. Lifespan, health span, survival in CL4176 Alzheimer’s model and molecular mechanism were analyzed.

RESULTS: Extract of Ocimum sanctumand eugenol increased lifespan and provided indemnity against pro- oxidants. It also significantly improved healthy ageing and slowed the progression of neurodegeneration in CL4176 Alzheimer’s model of worm by increasing survival against pro-oxidants and slowing down the paralysis. Longevity effect was independent of the DAF-16 as observed by using DAF-16::GFP and daf- 16 null mutant strains. These results implicate eugenol as a potent therapeutic compound which may curtail ageing and age related disorders like- Alzheimer’s disease.

CONCLUSION: The present work demonstrated eugenol as a potential anti-ageing compound which may curtail ageing, improve heath span by enhancing resistance to oxidative stress and exerts its effect independent of DAF-16 pathway. So, it can be assumed that eugenol can be beneficial to humans as well, albeit further research is necessary before declaring it for human consumption.

PMID:34629046 | DOI:10.2174/1871527320666211008150347

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About The Author

Patrick Blanchard MD

Meet Dr. Blanchard Dr. Blanchard’s medical practice is an embodiment of Integrative health which brings conventional and complementary approaches together in a coordinated way. Conveniently located in sunny Florida and over the internet with ValiseMD’s secure HIPPA compliant telXmed servers. Since 1994, patients with a wide range of challenging medical problems have achieved optimum health using the best of natural medicine, judiciously combined with high-tech innovations. Breakthroughs are often achieved even after patients have consulted mainstream specialists and holistic practitioners. Dr. Blanchard is founder and CEO of ValiseMD, Inc. He is board certified in Family Medicine since 1994 and awarded Fellow of the American Academy of Family Physicians in 2001. He received the ‘Teacher of the Year’ award from the University of Kansas School of Medicine at completion of his residency in Family Medicine. He completed a fellowship at Wake Forest University in the field of vascular neurosonology. He holds a medical patent in the field of Gastroenterology. He holds an unrestricted license to practice medicine and surgery in Florida. He started his medical career as a Emergency Medical Technician, then as a Paramedic and later a Medical Doctor.