Direct arene trifluoromethylation enabled by promiscuous activity of fungal laccase
November 7, 2023
Org Biomol Chem. 2023 Nov 7. doi: 10.1039/d3ob01779f. Online ahead of print.
ABSTRACT
Laccase from Trametes versicolor was found to oxidize non-phenolic arenes and enable the trifluoromethylation of arenes in the presence of in situ generated CF3 radicals at a catalyst loading as low as 0.0034%. The biocatalytic trifluoromethylation proceeded under mild conditions and could increase the yield by up to 12 fold, compared to the control.
PMID:37933470 | DOI:10.1039/d3ob01779f