Corydalis and Drug-Induced Liver Injury: A Series of 2 Cases

ACG Case Rep J. 2023 Dec 21;10(12):e01230. doi: 10.14309/crj.0000000000001230. eCollection 2023 Dec.

ABSTRACT

Corydalis is an herbal plant found in Asian countries. Research has demonstrated multiple health benefits. It has also been implicated in drug-induced liver injury. Cannabis dispensaries market a sleep aid which has corydalis as an active ingredient. We present 2 cases of corydalis-induced hepatotoxicity. An asymptomatic female patient exhibited a rise and fall of her transaminases coinciding with the consumption and rechallenge of this sleep aid. A man with symptoms consistent with liver dysfunction began taking the same sleep aid. With discontinuance, his liver function returned to normal. These 2 clinical cases provide evidence for corydalis-induced liver injury.

PMID:38130480 | PMC:PMC10735149 | DOI:10.14309/crj.0000000000001230