In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa
Sci Rep. 2020 Nov 23;10(1):20405. doi: 10.1038/s41598-020-77175-y. ABSTRACT The Cannabis sativa plant contains more than 120 cannabinoids. With the exceptions of ∆9-tetrahydrocannabinol (∆9-THC) and cannabidiol...
Disposition of cannabinoids and their metabolites in serum, oral fluid, sweat patch and urine from healthy individuals treated with pharmaceutical preparations of medical cannabis
Phytother Res. 2021 Mar;35(3):1646-1657. doi: 10.1002/ptr.6931. Epub 2020 Nov 6. ABSTRACT Recently, several countries authorized the use of cannabis flowering tops (dried inflorescences) with a...
Cannabis sativa extracts protect LDL from Cu2+-mediated oxidation
J Cannabis Res. 2020;2:37. doi: 10.1186/s42238-020-00042-0. Epub 2020 Oct 15. ABSTRACT BACKGROUND: Multiple therapeutic properties have been attributed to Cannabis sativa. However, further research is...
The effect of cannabis toxicity on a model microbiome bacterium epitomized by a panel of bioluminescent E. coli
Chemosphere. 2021 Jan;263:128241. doi: 10.1016/j.chemosphere.2020.128241. Epub 2020 Sep 3. ABSTRACT The world acceptance of medical cannabis slowly widens. Cannabinoids are known as the main therapeutic...
A single nucleotide polymorphism assay sheds light on the extent and distribution of genetic diversity, population structure and functional basis of key traits in cultivated north American cannabis
J Cannabis Res. 2020 Sep 11;2(1):26. doi: 10.1186/s42238-020-00036-y. ABSTRACT BACKGROUND: The taxonomic classification of Cannabis genus has been delineated through three main types: sativa (tall...
A new Cannabis genome assembly associates elevated cannabidiol (CBD) with hemp introgressed into marijuana
New Phytol. 2021 May;230(4):1665-1679. doi: 10.1111/nph.17243. Epub 2021 Feb 28. ABSTRACT Demand for cannabidiol (CBD), the predominant cannabinoid in hemp (Cannabis sativa), has favored cultivars...
In vitro cholinesterase inhibitory action of Cannabis sativa L. Cannabaceae and in silico study of its selected phytocompounds
In Silico Pharmacol. 2021 Jan 21;9(1):13. doi: 10.1007/s40203-021-00075-0. eCollection 2021. ABSTRACT Cannabis sativa L. Cannabaceae, used for psychoactive rituals in Mesopotamia. Here, we investigated in...
Disposition of Phytocannabinoids, Their Acidic Precursors and Their Metabolites in Biological Matrices of Healthy Individuals Treated with Vaporized Medical Cannabis
Pharmaceuticals (Basel). 2021 Jan 13;14(1):59. doi: 10.3390/ph14010059. ABSTRACT Inhalation by vaporization is a useful application mode for medical cannabis. In this study, we present the...
Cannabinoid Content in Cannabis Flowers and Homemade Cannabis-Based Products Used for Therapeutic Purposes in Argentina
Cannabis Cannabinoid Res. 2023 Feb;8(1):197-206. doi: 10.1089/can.2020.0117. Epub 2021 Mar 26. ABSTRACT Introduction: A recent law (DCTO-2020-883-APN-PTE-Law No. 27,350. Regulation) passed in Argentina put an...
Widely assumed phenotypic associations in Cannabis sativa lack a shared genetic basis
PeerJ. 2021 Apr 20;9:e10672. doi: 10.7717/peerj.10672. eCollection 2021. ABSTRACT The flowering plant Cannabis sativa, cultivated for centuries for multiple purposes, displays extensive variation in phenotypic...
Three novel transcription factors involved in cannabinoid biosynthesis in Cannabis sativa L
Plant Mol Biol. 2021 May;106(1-2):49-65. doi: 10.1007/s11103-021-01129-9. Epub 2021 Feb 24. ABSTRACT Three novel transcription factors were successfully identified and shown to interact with the...
SNP in Potentially Defunct Tetrahydrocannabinolic Acid Synthase Is a Marker for Cannabigerolic Acid Dominance in Cannabis sativa L
Genes (Basel). 2021 Feb 4;12(2):228. doi: 10.3390/genes12020228. ABSTRACT The regulation of cannabinoid synthesis in Cannabis sativa is of increasing research interest as restrictions around the...
The Highs and Lows of P Supply in Medical Cannabis: Effects on Cannabinoids, the Ionome, and Morpho-Physiology
Front Plant Sci. 2021 Jul 15;12:657323. doi: 10.3389/fpls.2021.657323. eCollection 2021. ABSTRACT Environmental conditions, including the availability of mineral nutrients, affect secondary metabolism in plants. Therefore,...
In Situ Decarboxylation-Pressurized Hot Water Extraction for Selective Extraction of Cannabinoids from Cannabis sativa. Chemometric Approach
Molecules. 2021 Jun 2;26(11):3343. doi: 10.3390/molecules26113343. ABSTRACT Isolation of the therapeutic cannabinoid compounds from Cannabis Sativa L. (C. Sativa) is important for the development of...
Detectability of cannabinoids in the serum samples of cannabis users: Indicators of recent cannabis use? A follow-up study
Drug Test Anal. 2021 Sep;13(9):1614-1626. doi: 10.1002/dta.3110. Epub 2021 Jun 21. ABSTRACT Forensic toxicologists are frequently required to predict the time of last cannabis consumption....