Intestinal bioavailability of n-3 long-chain polyunsaturated fatty acids influenced by the supramolecular form of phospholipids
Food Funct. 2020 Feb 26;11(2):1721-1728. doi: 10.1039/c9fo02953b. ABSTRACT The aim of this work was to study the bioavailability of n-3 long-chain polyunsaturated fatty acids (n-3...
Pharmacokinetics and bioavailability of hydroxytyrosol are dependent on the food matrix in humans
Eur J Nutr. 2021 Mar;60(2):905-915. doi: 10.1007/s00394-020-02295-0. Epub 2020 Jun 10. ABSTRACT PURPOSE: Several studies have demonstrated the properties of hydroxytyrosol, a phenolic compound present...
Monoacylglycerol Form of Omega-3s Improves Its Bioavailability in Humans Compared to Other Forms
Nutrients. 2020 Apr 7;12(4):1014. doi: 10.3390/nu12041014. ABSTRACT Numerous benefits are attributed to omega-3 fatty acids (OM3) especially in cardiovascular health. However, bioavailability and clinical efficacy...
Novel Biphasic Lipolysis Method To Predict in Vivo Performance of Lipid-Based Formulations
Mol Pharm. 2020 Sep 8;17(9):3342-3352. doi: 10.1021/acs.molpharmaceut.0c00427. Epub 2020 Aug 21. ABSTRACT The absence of an intestinal absorption sink is a significant weakness of standard...
Chase Dosing of Lipid Formulations to Enhance Oral Bioavailability of Nilotinib in Rats
Pharm Res. 2020 Jun 10;37(7):124. doi: 10.1007/s11095-020-02841-9. ABSTRACT PURPOSE: Lipid-based formulations (LBF) have shown oral bioavailability enhancement of lipophilic drugs, but not necessarily in the...
Natural sesame oil is superior to pre-digested lipid formulations and purified triglycerides in promoting the intestinal lymphatic transport and systemic bioavailability of cannabidiol
Eur J Pharm Biopharm. 2021 May;162:43-49. doi: 10.1016/j.ejpb.2021.02.013. Epub 2021 Mar 5. ABSTRACT Lipid-based formulations play a significant role in oral delivery of lipophilic drugs....
In vitro dissolution behaviour and absorption in humans of a novel mixed l-lysine salt formulation of EPA and DHA
Prostaglandins Leukot Essent Fatty Acids. 2021 Jan;164:102232. doi: 10.1016/j.plefa.2020.102232. Epub 2020 Dec 19. ABSTRACT INTRODUCTION: Supplements with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are...
Salmon food matrix influences digestion and bioavailability of long-chain omega-3 polyunsaturated fatty acids
Food Funct. 2021 Jul 21;12(14):6588-6602. doi: 10.1039/d1fo00475a. Epub 2021 Jun 8. ABSTRACT The natural structure of whole food plays an important role in the physiological...
Absorption, Distribution, Metabolism, and Excretion of the Main Olive Tree Phenols and Polyphenols: A Literature Review
J Agric Food Chem. 2021 May 12;69(18):5281-5296. doi: 10.1021/acs.jafc.1c00737. Epub 2021 Apr 28. ABSTRACT The effects of olive tree (poly)phenols (OPs) are largely dependent upon...
Olive oil and oleic acid-based self nano-emulsifying formulation of omega-3-fatty acids with improved strength, stability, and therapeutics
J Microencapsul. 2021 Aug;38(5):298-313. doi: 10.1080/02652048.2021.1914760. Epub 2021 May 17. ABSTRACT AIM: To develop, characterise, and optimise SNEDDS formulation to enhance organoleptics, bioavailability, physical &...
Impact of excipient emulsions made from different types of oils on the bioavailability and metabolism of curcumin in gastrointestinal tract
Food Chem. 2022 Feb 15;370:130980. doi: 10.1016/j.foodchem.2021.130980. Epub 2021 Aug 30. ABSTRACT Low bioavailability currently limits the potential of curcumin as a health-promoting dietary compound....
Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in Lipid-Based Formulations
Mol Pharm. 2021 Sep 6;18(9):3281-3289. doi: 10.1021/acs.molpharmaceut.1c00197. Epub 2021 Aug 5. ABSTRACT Lipid-based formulations, such as self-microemulsifying drug-delivery systems (SMEDDSs), are promising tools for the...
Medium Chain Triglycerides Promote the Uptake of β-Carotene in O/W Emulsions via Intestinal Transporter SR-B1 in Caco-2 Cells
J Agric Food Chem. 2022 Aug 3;70(30):9377-9387. doi: 10.1021/acs.jafc.2c02660. Epub 2022 Jul 21. ABSTRACT This study aimed to elucidate the impacts of carrier oil types...
Effect of Gum Acacia on the Intestinal Bioavailability of n-3 Polyunsaturated Fatty Acids in Rats
Biomolecules. 2022 Jul 12;12(7):975. doi: 10.3390/biom12070975. ABSTRACT Lipid emulsification is a technique that is being explored for improving the bioavailability of omega 3 (n-3) long...
Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults
N Engl J Med. 2022 Jul 28;387(4):299-309. doi: 10.1056/NEJMoa2202106. ABSTRACT BACKGROUND: Vitamin D supplements are widely recommended for bone health in the general population, but...