Correlating in Vitro Solubilization and Supersaturation Profiles with in Vivo Exposure for Lipid Based Formulations of the CETP Inhibitor CP-532,623
Mol Pharm. 2017 Dec 4;14(12):4525-4538. doi: 10.1021/acs.molpharmaceut.7b00660. Epub 2017 Nov 9. ABSTRACT Lipid based formulations (LBFs) are a promising formulation strategy for many poorly water-soluble...
Supersaturable Self-Emulsifying Drug Delivery System of Krill Oil with Improved Oral Absorption and Hypotriglyceridemic Function
J Agric Food Chem. 2018 May 30;66(21):5352-5358. doi: 10.1021/acs.jafc.8b00693. Epub 2018 May 21. ABSTRACT This study aimed to develop a supersaturable self-emulsifying drug delivery system...
Absorption rate of krill oil and fish oil in blood and brain of rats
Lipids Health Dis. 2018 Jul 18;17(1):162. doi: 10.1186/s12944-018-0812-7. ABSTRACT BACKGROUND: Krill (Euphausia superba) is a small marine crustacean with a lipid content. The mechanism of...
Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice
Nutrients. 2018 Jul 26;10(8):965. doi: 10.3390/nu10080965. ABSTRACT Microalgae are rich in macronutrients and therefore, they have been proposed as a potential future food source preserving...
Intrinsic and Extrinsic Factors Impacting Absorption, Metabolism, and Health Effects of Dietary Carotenoids
Adv Nutr. 2018 Jul 1;9(4):465-492. doi: 10.1093/advances/nmy025. ABSTRACT Carotenoids are orange, yellow, and red lipophilic pigments present in many fruit and vegetables, as well as...
Effects of a Self-micro-emulsifying Delivery System Formulation Versus a Standard ω-3 Acid Ethyl Ester Product on the Bioavailability of Eicosapentaenoic Acid and Docosahexaenoic Acid: A Study in Healthy Men and Women in a Fasted State
Clin Ther. 2018 Dec;40(12):2065-2076. doi: 10.1016/j.clinthera.2018.10.014. Epub 2018 Nov 16. ABSTRACT PURPOSE: Intakes of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with several...
Effect of linolenic acid on bioavailability of cadmium in eutrophic water
Wei Sheng Yan Jiu. 2018 Jul;47(4):644-661. ABSTRACT OBJECTIVE: To investigate the bioavailability of heavy metal cadmium on planktonic algae under the condition of containing linolenic...
Bioavailability of docosahexaenoic acid 22:6(n-3) from enantiopure triacylglycerols and their regioisomeric counterpart in rats
Food Chem. 2019 Jun 15;283:381-389. doi: 10.1016/j.foodchem.2018.12.130. Epub 2019 Jan 14. ABSTRACT Lack of synthetic enantiospecific triacylglycerols (TAGs) has hindered our understanding of the impact...
Strategies to improve bioavailability of omega-3 fatty acids from ethyl ester concentrates
Curr Opin Clin Nutr Metab Care. 2019 Mar;22(2):116-123. doi: 10.1097/MCO.0000000000000537. ABSTRACT PURPOSE OF REVIEW: To describe recent strategies that have been developed to enhance absorption...
In vitro lipolysis and lymphatic absorption of n-3 long-chain PUFA in the rat: influence of the molecular lipid species as carrier
Br J Nutr. 2019 Sep 28;122(6):639-647. doi: 10.1017/S0007114519001491. ABSTRACT The aim of this work was to study the bioavailability of fatty acids (FA), focusing on...
Thermal stability and bioavailability of inclusion complexes of perilla oil with γ-cyclodextrin
Food Chem. 2019 Oct 1;294:56-59. doi: 10.1016/j.foodchem.2019.04.093. Epub 2019 Apr 25. ABSTRACT Perilla oil is abundant in α-linolenic acid, which is metabolized to long-chain n-3...
Microencapsulated Tuna Oil Results in Higher Absorption of DHA in Toddlers
Nutrients. 2020 Jan 18;12(1):248. doi: 10.3390/nu12010248. ABSTRACT : Docosahexaenoic acid (DHA) is an essential component for brain and visual acuity development during foetal and early...
Oral administration of a synthetic vinyl-ether plasmalogen normalizes open field activity in a mouse model of rhizomelic chondrodysplasia punctata
Dis Model Mech. 2020 Jan 24;13(1):dmm042499. doi: 10.1242/dmm.042499. ABSTRACT Rhizomelic chondrodysplasia punctata (RCDP) is a rare genetic disorder caused by mutations in peroxisomal genes essential...
A self-emulsifying Omega-3 ethyl ester formulation (AquaCelle) significantly improves eicosapentaenoic and docosahexaenoic acid bioavailability in healthy adults
Eur J Nutr. 2020 Sep;59(6):2729-2737. doi: 10.1007/s00394-019-02118-x. Epub 2019 Oct 21. ABSTRACT PURPOSE: Application of intelligent formulation design has the ability to address the poor...
Effects of a plant-based fatty acid supplement and a powdered fruit, vegetable and berry juice concentrate on omega-3-indices and serum micronutrient concentrations in healthy subjects
Int J Food Sci Nutr. 2020 Sep;71(6):769-780. doi: 10.1080/09637486.2020.1725960. Epub 2020 Feb 17. ABSTRACT The major aim of this controlled, randomised, open-labelled, parallel-grouped, clinical trial...