Compensatory role of endogenous sulfur dioxide in nitric oxide deficiency-induced hypertension
Redox Biol. 2021 Nov 18;48:102192. doi: 10.1016/j.redox.2021.102192. Online ahead of print. ABSTRACT OBJECTIVE: This study aimed to determine the communicational pattern of gaseous signaling molecules...
Management of central hemodynamic and endothelial function disturbances in patients with myocardial infarction combined with metabolic syndrome
Pol Merkur Lekarski. 2021 Oct 22;49(293):325-328. ABSTRACT On a global scale, myocardial infarction (MI) remains one of the most important cardiological challenges of today due...
Oral L-Arginine (5 g/day) for 14 Days Improves Microcirculatory Function in Healthy Young Women and Healthy and Type 2 Diabetes Mellitus Elderly Women
J Vasc Res. 2021 Nov 16:1-10. doi: 10.1159/000519428. Online ahead of print. ABSTRACT OBJECTIVE: The aim of this study was to investigate the effect of...
Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
Exp Neurol. 2021 Nov 12;348:113923. doi: 10.1016/j.expneurol.2021.113923. Online ahead of print. ABSTRACT Arginase 1 (A1) is the enzyme that hydrolyzes the amino acid, L-arginine, to...
Roles of Endothelial Motilin Receptor and Its Signal Transduction Pathway in Motilin-Induced Left Gastric Artery Relaxation in Dogs
Front Physiol. 2021 Oct 28;12:770430. doi: 10.3389/fphys.2021.770430. eCollection 2021. ABSTRACT Background: Motilin increases left gastric artery (LGA) blood flow in dogs via the endothelial motilin...
Folic acid, either solely or combined with L-citrulline, improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs
Physiol Rep. 2021 Nov;9(21):e15096. doi: 10.14814/phy2.15096. ABSTRACT Concomitant with developing pulmonary hypertension (PH), newborn piglets exposed to chronic hypoxia develop pulmonary vascular NO signaling impairments....
Correlation between Apelin and Some Angiogenic Factors in the Pathogenesis of Preeclampsia: Apelin-13 as Novel Drug for Treating Preeclampsia and Its Physiological Effects on Placenta
Int J Endocrinol. 2021 Nov 15;2021:5017362. doi: 10.1155/2021/5017362. eCollection 2021. ABSTRACT Preeclampsia (PE) is one of the commonest causes for maternal and fetal morbidity and...
Involvement of Gap Junctions in Acetylcholine-Induced Endothelium-Derived Hyperpolarization-Type Dilation of Retinal Arterioles in Rats
Biol Pharm Bull. 2021;44(12):1860-1865. doi: 10.1248/bpb.b21-00547. ABSTRACT An electrical communication between the endothelial and smooth muscle cells via gap junctions, which provides the signaling pathway...
SNHG12 regulates biological behaviors of ox-LDL-induced HA-VSMCs through upregulation of SPRY2 and NUB1
Atherosclerosis. 2021 Nov 8;340:1-11. doi: 10.1016/j.atherosclerosis.2021.11.006. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Human vascular smooth muscle cells (HA-VSMCs) are an important cell type...
Cyanidin-3-O-glucoside supplementation ameliorates metabolic insulin resistance via restoration of nitric oxide-mediated endothelial insulin transport
Mol Nutr Food Res. 2021 Nov 28:e2100742. doi: 10.1002/mnfr.202100742. Online ahead of print. ABSTRACT SCOPE: Anthocyanin cyanidin-3-O-glucoside (Cy3G) has a great potential in prevention of...
Icariin accelerates cartilage defect repair by promoting chondrogenic differentiation of BMSCs under conditions of oxygen-glucose deprivation
J Cell Mol Med. 2021 Dec 3. doi: 10.1111/jcmm.17073. Online ahead of print. ABSTRACT This study explored the role played by combined ICA and bone...
3D printing of alginate dialdehyde-gelatin (ADA-GEL) hydrogels incorporating phytotherapeutic icariin loaded mesoporous SiO(2)-CaO nanoparticles for bone tissue engineering
Mater Sci Eng C Mater Biol Appl. 2021 Dec;131:112470. doi: 10.1016/j.msec.2021.112470. Epub 2021 Oct 2. ABSTRACT 3D printing enables a better control over the microstructure...
Icariin activates autophagy to trigger TGFbeta1 upregulation and promote angiogenesis in EA.hy926 human vascular endothelial cells
Bioengineered. 2021 Nov 30. doi: 10.1080/21655979.2021.2011637. Online ahead of print. ABSTRACT Angiogenesis plays an important role in tissue development and repair, and how to regulate...
Icariin Protects H9c2 Rat Cardiomyoblasts from Doxorubicin-Induced Cardiotoxicity: Role of Caveolin-1 Upregulation and Enhanced Autophagic Response
Nutrients. 2021 Nov 14;13(11):4070. doi: 10.3390/nu13114070. ABSTRACT Doxorubicin (Doxo) is a widely used antineoplastic drug which often induces cardiomyopathy, leading to congestive heart failure through...
Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia-Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model
Biomedicines. 2021 Nov 19;9(11):1719. doi: 10.3390/biomedicines9111719. ABSTRACT Stroke, which is the second leading cause of mortality in the world, is urgently needed to explore the...