Use of Selective Alternative Therapies for Treatment of OCD
Neuropsychiatr Dis Treat. 2023 Apr 5;19:721-732. doi: 10.2147/NDT.S403997. eCollection 2023. ABSTRACT About 40% of the people with the obsessive-compulsive-disorder do not experience the desired outcome...
CannaCount: an improved metric for quantifying estimates of maximum possible cannabinoid exposure
Sci Rep. 2023 Apr 11;13(1):5869. doi: 10.1038/s41598-023-32671-9. ABSTRACT Increasing numbers of individuals have access to cannabinoid-based products containing various amounts of delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD),...
The Cannabinoids, CBDA and THCA, Rescue Memory Deficits and Reduce Amyloid-Beta and Tau Pathology in an Alzheimer’s Disease-like Mouse Model
Int J Mol Sci. 2023 Apr 6;24(7):6827. doi: 10.3390/ijms24076827. ABSTRACT Most studies related to hemp are focused on Cannabidiol (CBD) and Tetrahydrocannabinol (THC); however, up...
Aβ Chronic Exposure Promotes an Activation State of Microglia through Endocannabinoid Signalling Imbalance
Int J Mol Sci. 2023 Apr 3;24(7):6684. doi: 10.3390/ijms24076684. ABSTRACT Dysfunctional phenotype of microglia, the primary brain immune cells, may aggravate Alzheimer’s disease (AD) pathogenesis...
Novel Cannabinoid Receptor 2 (CB2) Low Lipophilicity Agonists Produce Distinct cAMP and Arrestin Signalling Kinetics without Bias
Int J Mol Sci. 2023 Mar 29;24(7):6406. doi: 10.3390/ijms24076406. ABSTRACT Cannabinoid Receptor 2 (CB2) is a promising target for treating inflammatory diseases. We designed derivatives...
Lysophosphatidylinositol Promotes Chemotaxis and Cytokine Synthesis in Mast Cells with Differential Participation of GPR55 and CB2 Receptors
Int J Mol Sci. 2023 Mar 28;24(7):6316. doi: 10.3390/ijms24076316. ABSTRACT Mast cells (MCs) are the main participants in the control of immune reactions associated with...
Beta-Caryophyllene Modifies Intracellular Lipid Composition in a Cell Model of Hepatic Steatosis by Acting through CB2 and PPAR Receptors
Int J Mol Sci. 2023 Mar 23;24(7):6060. doi: 10.3390/ijms24076060. ABSTRACT Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease; however,...
Preliminary study of the interactive effects of THC and ethanol on self-reported ability and simulated driving, subjective effects, and cardiovascular responses
Psychopharmacology (Berl). 2023 Apr 12. doi: 10.1007/s00213-023-06356-0. Online ahead of print. ABSTRACT RATIONALE: Drug- and alcohol-related motor vehicle accidents are a leading cause of morbidity...
The Polypharmacological Effects of Cannabidiol
Molecules. 2023 Apr 6;28(7):3271. doi: 10.3390/molecules28073271. ABSTRACT Cannabidiol (CBD) is a major phytocannabinoid present in Cannabis sativa (Linneo, 1753). This naturally occurring secondary metabolite does...
Cannabis Extraction Technologies: Impact of Research and Value Addition in Latin America
Molecules. 2023 Mar 23;28(7):2895. doi: 10.3390/molecules28072895. ABSTRACT The Cannabis genus of plants has been widely used in different cultures for various purposes. It is separated...
Cannabidiol as a Modulator of the Development of Alcohol Tolerance in Rats
Nutrients. 2023 Mar 30;15(7):1702. doi: 10.3390/nu15071702. ABSTRACT The study aimed to explore in vivo the influence of cannabidiol (CBD) on the development of alcohol tolerance...
Las ‘Guías para el Uso de Cannabis de Menor Riesgo (GUCMR)’: RECOMENDACIONES [The ‘Lower-Risk Cannabis Use Guidelines (LRCUG)’: RECOMMENDATIONS (SPANISH)]
Int J Drug Policy. 2023 Apr 11:103996. doi: 10.1016/j.drugpo.2023.103996. Online ahead of print. NO ABSTRACT PMID:37055340 | DOI:10.1016/j.drugpo.2023.103996...
Les ‘Lignes Directrices Pour l’Usage du Cannabis à Moindre Risque (LUCMR)’: RECOMMENDATIONS [The ‘Lower-Risk Cannabis Use Guidelines (LRCUG)’: RECOMMENDATIONS (FRENCH)]
Int J Drug Policy. 2023 Apr 11:103994. doi: 10.1016/j.drugpo.2023.103994. Online ahead of print. NO ABSTRACT PMID:37055339 | DOI:10.1016/j.drugpo.2023.103994...
Normative Misperceptions About Cannabis Use in a Sample of Risky Cannabis Users
Subst Abuse. 2023 Apr 6;17:11782218231166809. doi: 10.1177/11782218231166809. eCollection 2023. ABSTRACT INTRODUCTION: This study examines normative misperceptions in a sample of participants recruited for a brief...
Evidence-Based Treatment of Pain in Chemotherapy-Induced Peripheral Neuropathy
Curr Pain Headache Rep. 2023 Apr 14. doi: 10.1007/s11916-023-01107-4. Online ahead of print. ABSTRACT PURPOSE OF REVIEW: Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and...