Severe Genotype, Pancreatic Insufficiency and Low Dose of Pancreatic Enzymes Associate with Abnormal Serum Sterol Profile in Cystic Fibrosis
Biomolecules. 2021 Feb 19;11(2):313. doi: 10.3390/biom11020313. ABSTRACT BACKGROUND: Several factors could lead to lipid disturbances observed in cystic fibrosis (CF). This study aimed to assess...
24(S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer’s Disease
Mar Drugs. 2021 Mar 27;19(4):190. doi: 10.3390/md19040190. ABSTRACT We recently found that dietary supplementation with the seaweed Sargassum fusiforme, containing the preferential LXRβ-agonist 24(S)-saringosterol, prevented...
Sterol sulfate alleviates atherosclerosis via mediating hepatic cholesterol metabolism in ApoE-/- mice
Food Funct. 2021 Jun 8;12(11):4887-4896. doi: 10.1039/d0fo03266b. ABSTRACT Compared with terrestrial organisms, the sterols in sea cucumber exhibit a sulfate group at the C-3 position....
Effects of phytosterol supplementation on growth performance, serum lipid, proinflammatory cytokines, intestinal morphology, and meat quality of white feather broilers
Poult Sci. 2021 Jul;100(7):101096. doi: 10.1016/j.psj.2021.101096. Epub 2021 Mar 12. ABSTRACT The aim of this study was to evaluate the effects of dietary phytosterol (PS)...
Amelioration of Chlorpyrifos-Induced Toxicity in Brassica juncea L. by Combination of 24-Epibrassinolide and Plant-Growth-Promoting Rhizobacteria
Biomolecules. 2021 Jun 12;11(6):877. doi: 10.3390/biom11060877. ABSTRACT Pervasive use of chlorpyrifos (CP), an organophosphorus pesticide, has been proven to be fatal for plant growth, especially...
Phytosterols and Cardiovascular Disease
Curr Atheroscler Rep. 2021 Sep 1;23(11):68. doi: 10.1007/s11883-021-00964-x. ABSTRACT PURPOSE OF REVIEW: Coronary heart disease is the leading cause of mortality worldwide. Elevated blood cholesterol...
Efficient One-Step Biocatalytic Multienzyme Cascade Strategy for Direct Conversion of Phytosterol to C-17-Hydroxylated Steroids
Appl Environ Microbiol. 2021 Nov 24;87(24):e0032121. doi: 10.1128/AEM.00321-21. Epub 2021 Sep 29. ABSTRACT Steroidal 17-carbonyl reduction is crucial to the production of natural bioactive steroid...
Hydrogen sulfide attenuates hyperhomocysteinemia-induced blood-brain barrier permeability by inhibiting MMP-9
Int J Neurosci. 2021 Feb 1:1-11. doi: 10.1080/00207454.2020.1860967. Online ahead of print. ABSTRACT Backgroud: Hyperhomocysteinemia (HHcy) is implicated in various neurovascular disorders including vascular dementia,...
Plasma Vitamin B12 Levels, High-Dose Vitamin B12 Treatment, and Risk of Dementia
J Alzheimers Dis. 2021;79(4):1601-1612. doi: 10.3233/JAD-201096. ABSTRACT BACKGROUND: It is controversial whether B12 deficiency causes dementia or B12 treatment can prevent dementia. OBJECTIVE: To assess...
Safety of water extract of Cistanche tubulosa stems as a Novel food pursuant to Regulation (EU) 2015/2283
EFSA J. 2021 Jan 15;19(1):e06346. doi: 10.2903/j.efsa.2021.6346. eCollection 2021 Jan. ABSTRACT Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods...
Ubiquinol Supplementation Improves Gender-Dependent Cerebral Vasoreactivity and Ameliorates Chronic Inflammation and Endothelial Dysfunction in Patients with Mild Cognitive Impairment
Antioxidants (Basel). 2021 Jan 20;10(2):143. doi: 10.3390/antiox10020143. ABSTRACT Ubiquinol can protect endothelial cells from multiple mechanisms that cause endothelial damage and vascular dysfunction, thus contributing...
Association Between Homocysteine and Vitamin Levels in Demented Patients
J Alzheimers Dis. 2021;81(4):1781-1792. doi: 10.3233/JAD-201481. ABSTRACT BACKGROUND: Although it is known that the nutritional status among elderly persons and, in particular, patients with dementia,...
Migraine and Vascular Risk: An Update
Neurol India. 2021 Mar-Apr;69(Supplement):S83-S90. doi: 10.4103/0028-3886.315974. ABSTRACT BACKGROUND: Migraine is a common neurological disorder with significant morbidity and disability. There is growing evidence that migraine...
Contrasting Metabolic Insufficiency in Aging and Dementia
Aging Dis. 2021 Jul 1;12(4):1081-1096. doi: 10.14336/AD.2021.0104. eCollection 2021 Jul. ABSTRACT Metabolic insufficiency and neuronal dysfunction occur in normal aging but is exaggerated in dementia...
Effects of Supplementation with Folic Acid and Its Combinations with Other Nutrients on Cognitive Impairment and Alzheimer’s Disease: A Narrative Review
Nutrients. 2021 Aug 26;13(9):2966. doi: 10.3390/nu13092966. ABSTRACT Cognitive impairment and Alzheimer’s Disease, among other cognitive dysfunctions, has been recognized as a major public health problem....