Antiaging effect of anthocyanin extracts from bilberry on natural or UV-treated male Drosophila melanogaster
Curr Res Food Sci. 2022 Sep 19;5:1640-1648. doi: 10.1016/j.crfs.2022.09.015. eCollection 2022.
ABSTRACT
Anthocyanins from bilberry (Vaccinium vitis-idaea) are one of the most abundant sources of polyphenols and are widely used in the food, medicine and cosmetics industries due to their antioxidation properties, but few studies have investigated their antiaging properties. Based on our previous examination, the effect of anthocyanin extracts from bilberry (BANCs) on several characteristics of natural and UV-treated male Drosophila melanogaster, including their lifespan, fecundity, and antioxidant capacity, was studied, and the related mechanisms were preliminary explored. The results indicated that BANCs can effectively prolong the average and maximum lifespan and improve the reproductive capacity and antioxidant capacity of natural and UV-treated flies. In particular, BANCs significantly changed the growth cycle, sex ratio and content of ROS in the fat bodies of the offspring and decreased the expression levels of antioxidant- and autophagy-related genes in UV-treated flies. Collectively, the results demonstrate that BANC supplementation in the medium effectively alleviated the aging process, and this effect was not directly correlated with the antioxidant and autophagy signaling pathways in the body of D. melanogaster.
PMID:36187878 | PMC:PMC9516408 | DOI:10.1016/j.crfs.2022.09.015
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About The Author
Patrick Blanchard MD
Meet Dr. Blanchard Dr. Blanchard’s medical practice is an embodiment of Integrative health which brings conventional and complementary approaches together in a coordinated way. Conveniently located in sunny Florida and over the internet with ValiseMD’s secure HIPPA compliant telXmed servers. Since 1994, patients with a wide range of challenging medical problems have achieved optimum health using the best of natural medicine, judiciously combined with high-tech innovations. Breakthroughs are often achieved even after patients have consulted mainstream specialists and holistic practitioners. Dr. Blanchard is founder and CEO of ValiseMD, Inc. He is board certified in Family Medicine since 1994 and awarded Fellow of the American Academy of Family Physicians in 2001. He received the ‘Teacher of the Year’ award from the University of Kansas School of Medicine at completion of his residency in Family Medicine. He completed a fellowship at Wake Forest University in the field of vascular neurosonology. He holds a medical patent in the field of Gastroenterology. He holds an unrestricted license to practice medicine and surgery in Florida. He started his medical career as a Emergency Medical Technician, then as a Paramedic and later a Medical Doctor.