HomeIngredientA new perspective on the treatment of Alzheimer’s disease and sleep deprivation-related conse-quences: Curcumin

A new perspective on the treatment of Alzheimer’s disease and sleep deprivation-related conse-quences: Curcumin

February 18, 2022

Curr Pharm Biotechnol. 2022 Feb 17. doi: 10.2174/1389201023666220217115738. Online ahead of print.

ABSTRACT

Sleep problems and Alzheimer’s Disease (AD) are two disorders often seen together. Age-related structural and physiological changes in certain parts of the brain lead to changes in sleep patterns. Conditions such as AD also affect these areas of the brain, thus changing the sleep-wake cycle. Sleep disorders likewise adversely affect the course of the disease. Sleep quality is important for the proper functioning of the memory. Impaired sleep is also associated with problems in some areas of the brain that play a key role in learning and memory functions. Changes in the brain seen in aging and AD disrupt sleep and memory processes, leading increased cognitive impairment. In addition to synthetic drugs, treatment with plants has also become a preferred factor in the treatment. Curcuminoids, which are in the structure of diarylheptanoid, are the main components of turmeric. Curcumin has multiple applications in treatment regimes of various diseases such as cardiovascular diseases, obesity, cancer, inflammatory diseases, and aging. Besides these applications and activities, curcumin has been reported to be effective in many neurodegenerative diseases. There are plenty of studies show-ing that curcumin can lead significant improvements in the pathological process of AD. Despite many important positive effects, the therapeutic limitation of curcumin is its low solubility and bioavailabil-ity. New approaches are needed to solve this problem and many studies have focused different types of advanced nanoformulations. This review summarizes the available scientific data, as reported by the most recent studies describing the treatment of Alzheimer’s Disease and sleep deprivation-related consequences.

PMID:35176983 | DOI:10.2174/1389201023666220217115738

Tags:,

Related Posts

About The Author

Patrick Blanchard MD

Meet Dr. Blanchard Dr. Blanchard’s medical practice is an embodiment of Integrative health which brings conventional and complementary approaches together in a coordinated way. Conveniently located in sunny Florida and over the internet with ValiseMD’s secure HIPPA compliant telXmed servers. Since 1994, patients with a wide range of challenging medical problems have achieved optimum health using the best of natural medicine, judiciously combined with high-tech innovations. Breakthroughs are often achieved even after patients have consulted mainstream specialists and holistic practitioners. Dr. Blanchard is founder and CEO of ValiseMD, Inc. He is board certified in Family Medicine since 1994 and awarded Fellow of the American Academy of Family Physicians in 2001. He received the ‘Teacher of the Year’ award from the University of Kansas School of Medicine at completion of his residency in Family Medicine. He completed a fellowship at Wake Forest University in the field of vascular neurosonology. He holds a medical patent in the field of Gastroenterology. He holds an unrestricted license to practice medicine and surgery in Florida. He started his medical career as a Emergency Medical Technician, then as a Paramedic and later a Medical Doctor.