Total Synthesis of the Dimeric Phytocannabinoid Cannabitwinol (CBD Dimer) and Its Analogues
August 26, 2024
J Nat Prod. 2024 Aug 26. doi: 10.1021/acs.jnatprod.4c00674. Online ahead of print.
ABSTRACT
A new synthetic route to access the natural product phytocannabinoid cannabitwinol (1) starting from commercially available raw materials is disclosed. We have also demonstrated the synthesis of other related dimers, including their enantiomers, using the present sequence. This route avoids the legal constraints concerning the acquisition of cannabis plant material or CBD.
PMID:39185742 | DOI:10.1021/acs.jnatprod.4c00674