A novel multi-target strategy for Alzheimer’s disease treatment via sublingual route: Donepezil/memantine/curcumin-loaded nanofibers
Biomater Adv. 2022 Jul;138:212870. doi: 10.1016/j.bioadv.2022.212870. Epub 2022 May 18. ABSTRACT Drug delivery systems that not only show efficacy through multiple therapeutic pathways but also...
Antioxidant and Neuroprotective Effects of L-arginine Administration After Traumatic Brain Injury and Hemorrhagic Shock in Rats
Turk Neurosurg. 2022 Feb 2. doi: 10.5137/1019-5149.JTN.35263-21.2. Online ahead of print. ABSTRACT AIM: The aim of the current study was to investigate the effect of...
High-Throughput Sequencing and Bioinformatics analysis reveals the neurogenesis key targets of Curcumin action in mouse brain with MCAO
Comb Chem High Throughput Screen. 2022 Aug 3. doi: 10.2174/1386207325666220803090112. Online ahead of print. ABSTRACT BACKGROUND: Experimental studies have shown that Curcumin exerts neuroprotective effects...
Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism
Front Immunol. 2022 Jul 22;13:943321. doi: 10.3389/fimmu.2022.943321. eCollection 2022. ABSTRACT Quercetin, a naturally non-toxic flavonoid within the safe dose range with antioxidant, anti-apoptotic and anti-inflammatory...
Natural Antioxidant Compounds as Potential Pharmaceutical Tools against Neurodegenerative Diseases
ACS Omega. 2022 Jul 19;7(30):25974-25990. doi: 10.1021/acsomega.2c03291. eCollection 2022 Aug 2. ABSTRACT Natural antioxidants are a very large diversified family of molecules classified by activity...
An update on molecular mechanisms of curcumin effect on diabetes
J Food Biochem. 2022 Aug 9:e14358. doi: 10.1111/jfbc.14358. Online ahead of print. ABSTRACT Owing to its prevalent nature, diabetes mellitus has become one of the...
Protective Effect of Curcuma Extract in an Ex Vivo Model of Retinal Degeneration via Antioxidant Activity and Targeting the SUMOylation
Oxid Med Cell Longev. 2022 Jul 29;2022:8923615. doi: 10.1155/2022/8923615. eCollection 2022. ABSTRACT Retinal degeneration is the major and principal cause behind many incurable blindness diseases....
Expanding Arsenal against Neurodegenerative Diseases using Quercetin based Nanoformulations: Breakthroughs and Bottlenecks
Curr Neuropharmacol. 2022 Aug 10. doi: 10.2174/1570159X20666220810105421. Online ahead of print. ABSTRACT Quercetin (Qu), a dietary flavonoid, is obtained from many fruits and vegetables such...
Therapeutic Potential of Quercetin and its Derivatives in Epilepsy: Evidence from Preclinical Studies
Neuromolecular Med. 2022 Aug 11. doi: 10.1007/s12017-022-08724-z. Online ahead of print. ABSTRACT Quercetin is a polyphenolic bioactive compound highly enriched in dietary fruits, vegetables, nuts,...
Expanding Arsenal against Neurodegenerative Diseases using Quercetin based Nanoformulations: Breakthroughs and Bottlenecks
Curr Neuropharmacol. 2022 Aug 10. doi: 10.2174/1570159X20666220810105421. Online ahead of print. ABSTRACT Quercetin (Qu), a dietary flavonoid, is obtained from many fruits and vegetables such...
Targeting Oxidative Stress Mechanisms to Treat Alzheimer’s and Parkinson’s Disease: A Critical Review
Oxid Med Cell Longev. 2022 Jul 31;2022:7934442. doi: 10.1155/2022/7934442. eCollection 2022. ABSTRACT Neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are becoming...
Advances on nanoformulation approaches for delivering plant-derived antioxidants: A case of quercetin
Int J Pharm. 2022 Aug 8:122093. doi: 10.1016/j.ijpharm.2022.122093. Online ahead of print. ABSTRACT Oxidative stress has been implicated in tumorigenic, cardiovascular, neuro-, and age-related degenerative...
Therapeutic Role of Curcumin in Diabetes: An Analysis Based on Bioinformatic Findings
Nutrients. 2022 Aug 8;14(15):3244. doi: 10.3390/nu14153244. ABSTRACT BACKGROUND: Diabetes is an increasingly prevalent global disease caused by the impairment in insulin production or insulin function....
Ultrasmall Coordination Polymers for Alleviating ROS-Mediated Inflammatory and Realizing Neuroprotection against Parkinson’s Disease
Research (Wash D C). 2022 Jul 18;2022:9781323. doi: 10.34133/2022/9781323. eCollection 2022. ABSTRACT Parkinson’s disease (PD) is the second most common neurodegenerative disease globally, and there...
Mechanisms behind the Fibrillation and Toxicity of Insulin Fibrils on Neuron Cells by Engineered Curcumin Analogs
ACS Chem Neurosci. 2022 Aug 15. doi: 10.1021/acschemneuro.2c00209. Online ahead of print. ABSTRACT Among foods, the use of plant derivatives as promising drugs and/or excipients...