Anti-cancer potentiality of linoelaidic acid isolated from marine Tapra fish oil (Ophisthopterus tardoore) via ROS generation and caspase activation on MCF-7 cell line
Sci Rep. 2023 Aug 29;13(1):14125. doi: 10.1038/s41598-023-34885-3. ABSTRACT The implication of inflammation in the pathophysiology of several types of cancers has been under intense investigation....
Mechanisms Involved in the Therapeutic Effect of Cannabinoid Compounds on Gliomas: A Review with Experimental Approach
Curr Protein Pept Sci. 2023 Aug 30. doi: 10.2174/1389203724666230830125423. Online ahead of print. ABSTRACT INTRODUCTION: Brain tumors have high morbidity and mortality rates, accounting for...
Mercury distribution in plants and soils from the former mining area of Abbadia San Salvatore (Tuscany, Central Italy)
Environ Geochem Health. 2023 Aug 30. doi: 10.1007/s10653-023-01739-w. Online ahead of print. ABSTRACT The distribution of heavy metals in plants (Castanea sativa, Sambucus nigra, Verbascum...
Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators
Cell Chem Biol. 2023 Aug 21:S2451-9456(23)00249-0. doi: 10.1016/j.chembiol.2023.08.001. Online ahead of print. ABSTRACT Cannabinoids are phytochemicals from cannabis with anti-inflammatory actions in immune cells. Lipid...
Balancing risks and benefits of cannabis use: umbrella review of meta-analyses of randomised controlled trials and observational studies
BMJ. 2023 Aug 30;382:e072348. doi: 10.1136/bmj-2022-072348. ABSTRACT OBJECTIVE: To systematically assess credibility and certainty of associations between cannabis, cannabinoids, and cannabis based medicines and human...
Structural and functional insights into the G protein-coupled receptors: CB1 and CB2
Biochem Soc Trans. 2023 Aug 31;51(4):1533-1543. doi: 10.1042/BST20221316. ABSTRACT The cannabinoid receptors CB1 and CB2 mediate a variety of physiological processes and continue to be...
Blood and Urinary Metal Levels among Exclusive Marijuana Users in NHANES (2005-2018)
Environ Health Perspect. 2023 Aug;131(8):87019. doi: 10.1289/EHP12074. Epub 2023 Aug 30. ABSTRACT BACKGROUND: Marijuana is the third most used drug in the world. OBJECTIVES: Because...
Trends in Fatal Poisoning Among Drug Users in France From 2011 to 2021: An Analysis of the DRAMES Register
JAMA Netw Open. 2023 Aug 1;6(8):e2331398. doi: 10.1001/jamanetworkopen.2023.31398. ABSTRACT IMPORTANCE: The DRAMES (Décès en Relation avec l’Abus de Médicaments Et de Substances) register is a...
Parental openness and communication regarding cannabis and alcohol use with their children
Am J Addict. 2023 Aug 29. doi: 10.1111/ajad.13466. Online ahead of print. ABSTRACT BACKGROUND AND OBJECTIVES: Given increases in youth cannabis and alcohol use and...
The Leu/Val6.51 Side Chain of Cannabinoid Receptors Regulates the Binding Mode of the Alkyl Chain of Δ9-Tetrahydrocannabinol
J Chem Inf Model. 2023 Aug 29. doi: 10.1021/acs.jcim.3c01054. Online ahead of print. ABSTRACT (-)-Δ9-trans-tetrahydrocannabinol (THC), which is the principal psychoactive constituent of Cannabis, mediates...
Delta-9-tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: A within-subject, randomized, placebo-controlled laboratory study
Addict Biol. 2023 Sep;28(9):e13317. doi: 10.1111/adb.13317. ABSTRACT The opioid and cannabinoid receptor systems are inextricably linked-overlapping at the anatomical, functional and behavioural levels. Preclinical studies...
MICROGLIAL CELL EXPRESSION OF THE TYPE 2 CANNABINOID RECEPTOR REGULATES IMMUNE-MEDIATED NEUROINFLAMMATION
bioRxiv. 2023 Aug 14:2023.08.10.552854. doi: 10.1101/2023.08.10.552854. Preprint. ABSTRACT Neuroinflammation is a recognized complication of immunotherapeutic approaches such as immune checkpoint inhibitor treatment, chimeric antigen receptor...
ENDOCANNABINOID SYSTEM AND AGGRESSION ACROSS ANIMAL SPECIES
Neurosci Biobehav Rev. 2023 Aug 27:105375. doi: 10.1016/j.neubiorev.2023.105375. Online ahead of print. ABSTRACT This narrative review article summarizes the current state of knowledge regarding the...
ENDOCANNABINOID SYSTEM AND AGGRESSION ACROSS ANIMAL SPECIES
Neurosci Biobehav Rev. 2023 Aug 27:105375. doi: 10.1016/j.neubiorev.2023.105375. Online ahead of print. ABSTRACT This narrative review article summarizes the current state of knowledge regarding the...
Pharmacokinetics of Cannabidiol: A Systematic Review and Meta-Regression Analysis
Cannabis Cannabinoid Res. 2023 Aug 29. doi: 10.1089/can.2023.0025. Online ahead of print. ABSTRACT Background: In this review, we provide an updated assessment of available evidence...