Flavonoid-Rich Sambucus nigra Berry Extract Enhances Nrf2/HO-1 Signaling Pathway Activation and Exerts Antiulcerative Effects In Vivo
Int J Mol Sci. 2023 Oct 23;24(20):15486. doi: 10.3390/ijms242015486. ABSTRACT Sambucus nigra (SN) berry extract is characterized by high antioxidant and anti-inflammatory activity. The current...
Postbiotics Production of Candidate-Probiotic Lactiplantibacillus plantarum AC131 with Renewable Bio Resources
Life (Basel). 2023 Oct 2;13(10):2006. doi: 10.3390/life13102006. ABSTRACT Lactiplantibacillus plantarum is a versatile specie, well known as a producer of lactic acid (LA) and other...
In vitro and in vivo pharmacokinetic characterization, chiral conversion and PBPK scaling towards human PK simulation of S-MRI-1867, a drug candidate for Hermansky-Pudlak syndrome pulmonary fibrosis
Biomed Pharmacother. 2023 Oct 25;168:115178. doi: 10.1016/j.biopha.2023.115178. Online ahead of print. ABSTRACT Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder that affects lysosome-related organelles,...
Development of an efficient yeast platform for cannabigerolic acid biosynthesis
Metab Eng. 2023 Oct 25:S1096-7176(23)00144-1. doi: 10.1016/j.ymben.2023.10.004. Online ahead of print. ABSTRACT Cannabinoids are important therapeutical molecules for human ailments, cancer treatment, and SARS-CoV-2. The...
Circulating Endocannabinoids and N-Acylethanolamines in Individuals with Cannabis Use Disorder-Preliminary Findings
Brain Sci. 2023 Sep 27;13(10):1375. doi: 10.3390/brainsci13101375. ABSTRACT BACKGROUND: Endocannabinoids and related N-acylethanolamines (NAEs) are bioactive lipids with important physiological functions and putative roles in...
The Antioxidant and Neuroprotective Potential of Leaves and Inflorescences Extracts of Selected Hemp Varieties Obtained with scCO2
Antioxidants (Basel). 2023 Oct 4;12(10):1827. doi: 10.3390/antiox12101827. ABSTRACT Cannabis sativa, a versatile plant with numerous varieties, holds promising potential for a wide range of biological...
β-Caryophyllene Inhibits Oxaliplatin-Induced Peripheral Neuropathy in Mice: Role of Cannabinoid Type 2 Receptors, Oxidative Stress and Neuroinflammation
Antioxidants (Basel). 2023 Oct 22;12(10):1893. doi: 10.3390/antiox12101893. ABSTRACT Peripheral neuropathy is an important adverse effect caused by some chemotherapeutic agents, including oxaliplatin (OXA). OXA-induced peripheral...
The Main Therapeutic Applications of Cannabidiol (CBD) and Its Potential Effects on Aging with Respect to Alzheimer’s Disease
Biomolecules. 2023 Sep 26;13(10):1446. doi: 10.3390/biom13101446. ABSTRACT The use of cannabinoids (substances contained specifically in hemp plants) for therapeutic purposes has received increased attention in...
Influence of the Synthetic Cannabinoid Agonist on Normal and Inflamed Cartilage: An In Vitro Study
Biomolecules. 2023 Oct 10;13(10):1502. doi: 10.3390/biom13101502. ABSTRACT Medical marijuana (versus Marijuana derivatives) has been reported to possess analgesic, immunomodulatory, and anti-inflammatory properties. Recent studies in...
Therapeutic Potential of Cannabis: A Comprehensive Review of Current and Future Applications
Biomedicines. 2023 Sep 25;11(10):2630. doi: 10.3390/biomedicines11102630. ABSTRACT Historically, cannabis has been valued for its pain-relieving, anti-inflammatory, and calming properties. Ancient civilizations like the Egyptians, Greeks,...
Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System
Biomedicines. 2023 Sep 26;11(10):2642. doi: 10.3390/biomedicines11102642. ABSTRACT Neuroinflammation is a complex biological process that typically originates as a protective response in the brain. This inflammatory...
Cannabidiol Modulates M-Type K+ and Hyperpolarization-Activated Cation Currents
Biomedicines. 2023 Sep 27;11(10):2651. doi: 10.3390/biomedicines11102651. ABSTRACT Cannabidiol (CBD) is a naturally occurring compound found in the Cannabis plant that is known for its potential...
Medical Cannabis Is Not Associated with a Decrease in Activities of Daily Living in Older Adults
Biomedicines. 2023 Oct 3;11(10):2697. doi: 10.3390/biomedicines11102697. ABSTRACT The proportion of older adults using medical cannabis is rising. Therefore, we aimed to assess the effects of...
Beta-Caryophyllene, a Plant-Derived CB2 Receptor Agonist, Protects SH-SY5Y Cells from Cadmium-Induced Toxicity
Int J Mol Sci. 2023 Oct 23;24(20):15487. doi: 10.3390/ijms242015487. ABSTRACT Cadmium (Cd) is a transition heavy metal that is able to accumulate in the central...
Evaluating Sex Differences in Efficacy, Safety and Pharmacokinetics in Patients Treated with Cannabis by a Metered-Dose Inhaler
Pharmaceuticals (Basel). 2023 Oct 8;16(10):1426. doi: 10.3390/ph16101426. ABSTRACT BACKGROUND: Clinical studies on medical cannabis (MC) treatment have shown sex-related differences, including higher susceptibility to adverse...