HomeDiseaseNeuroprotective effects of Shogaol in metals (Al, As and Pb) and high fat diet induced neuroinflammation and behavior in mice

Neuroprotective effects of Shogaol in metals (Al, As and Pb) and high fat diet induced neuroinflammation and behavior in mice

December 25, 2022

Curr Mol Pharmacol. 2022 Sep 28. doi: 10.2174/1874467215666220928110557. Online ahead of print.

ABSTRACT

BACKGROUND: Increased exposure of humans to toxic metals and high fat diet (HFD) consumption severely damages brain health. Natural plant extracts have shown huge potential to treat multiple human diseases.

OBJECTIVE: The present study was designed to evaluate the protective effects of Shogaol (an active component of ginger) in neuroinflammation and behavioral paradigms in mice treated with metals and HFD.

METHODS: 8-11 weeks old male mice model was developed by giving a combination of metals i.e. Arsenic (As), Lead (Pb) and Aluminum (Al), 25mg/kg each mixed in drinking water with laboratory prepared HFD (40% fat) for a total duration of 72 days. Shogaol treated groups received two doses (2mg/kg & 12mg/kg) of shogaol along with metals and HFD. The biochemical parameters including body weights, blood glucose, kidney and liver functions were assessed along with the integrity of blood brain barrier (BBB). The expression analysis of neuroinflammatory genes (TNF-α, IL-1β & GFAP) was performed using q-PCR in the hippocampus and cortex. The exploratory and anxiety like behavior was assessed using open filed, and depressive behavior was assessed through forced swim test, while learning and memory were assessed using Morris water maze test and y- maze test.

RESULTS: Shogaol (2mg/kg & 12mg/kg) treatment improved metabolic profile and reduced expression of neuroinflammatory genes in the cortex and the hippocampus. Shogaol treatment improved BBB integrity. Results of behavioral analysis showed that Shogaol treatment (2mg/kg & 12mg/kg) rescued behavioral impairment and improved anxiety and depression.

CONCLUSION: Shogaol treatment showed strong therapeutic potential in metals & HFD induced neuroinflammation and improved cognitive functions, thus, can be considered as a potential drug candidate in future.

PMID:36173059 | DOI:10.2174/1874467215666220928110557

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About The Author

Patrick Blanchard MD

Meet Dr. Blanchard Dr. Blanchard’s medical practice is an embodiment of Integrative health which brings conventional and complementary approaches together in a coordinated way. Conveniently located in sunny Florida and over the internet with ValiseMD’s secure HIPPA compliant telXmed servers. Since 1994, patients with a wide range of challenging medical problems have achieved optimum health using the best of natural medicine, judiciously combined with high-tech innovations. Breakthroughs are often achieved even after patients have consulted mainstream specialists and holistic practitioners. Dr. Blanchard is founder and CEO of ValiseMD, Inc. He is board certified in Family Medicine since 1994 and awarded Fellow of the American Academy of Family Physicians in 2001. He received the ‘Teacher of the Year’ award from the University of Kansas School of Medicine at completion of his residency in Family Medicine. He completed a fellowship at Wake Forest University in the field of vascular neurosonology. He holds a medical patent in the field of Gastroenterology. He holds an unrestricted license to practice medicine and surgery in Florida. He started his medical career as a Emergency Medical Technician, then as a Paramedic and later a Medical Doctor.