HomeDiseaseIntrinsically Bioactive Manganese-eumelanin Nanocomposites Mediated Antioxidation and Anti-neuroinflammation for Targeted Theranostics of Traumatic Brain Injury

Intrinsically Bioactive Manganese-eumelanin Nanocomposites Mediated Antioxidation and Anti-neuroinflammation for Targeted Theranostics of Traumatic Brain Injury

August 20, 2022

Adv Healthc Mater. 2022 Jun 13:e2200517. doi: 10.1002/adhm.202200517. Online ahead of print.

ABSTRACT

Overproduced reactive oxygen species and the induced oxidative stress and neuroinflammation often result in secondary injury, which is associated with unfavorable prognosis in traumatic brain injury (TBI). Unfortunately, current medications cannot effectively ameliorate the secondary injury at traumatic sites. Here, we report that intrinsically bioactive multifunctional nanocomposites (termed as AMEC) mediated antioxidation and anti-neuroinflammation for targeted TBI theranostics, which are engineered by loading the neuroprotective agent curcumin on angiopep-2 functionalized and manganese doped eumelanin-like nanoparticles. After intravenous delivery, efficient AMEC accumulation was observed in lesions of TBI mice models established by controlled cortical impact method, evidenced by T1 -T2 magnetic resonance and photoacoustic dual-modal imaging. Therapeutically, AMEC effectively alleviated neuroinflammation, protected blood-brain barrier integrity, relieved brain edema, reduced brain tissue loss, mitigated hydrocephalus, and improved the cognition of TBI mice. Mechanistically, following the penetration into the traumatic tissues via angiopep-2 mediated targeting effect, the efficacy of AMEC was synergistically improved by combined functional moieties of curcumin and eumelanin. This was achieved by the alleviation of oxidative stress, inhibition of neuroinflammation via M1-to-M2 macrophage reprogramming, and promotion of neuronal regeneration. The as-developed AMEC with well-defined mechanisms of action may represent a promising targeted theranostics strategy for TBI and other neuroinflammation-associated intracranial diseases. This article is protected by copyright. All rights reserved.

PMID:35695187 | DOI:10.1002/adhm.202200517

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About The Author

Patrick Blanchard MD

Meet Dr. Blanchard Dr. Blanchard’s medical practice is an embodiment of Integrative health which brings conventional and complementary approaches together in a coordinated way. Conveniently located in sunny Florida and over the internet with ValiseMD’s secure HIPPA compliant telXmed servers. Since 1994, patients with a wide range of challenging medical problems have achieved optimum health using the best of natural medicine, judiciously combined with high-tech innovations. Breakthroughs are often achieved even after patients have consulted mainstream specialists and holistic practitioners. Dr. Blanchard is founder and CEO of ValiseMD, Inc. He is board certified in Family Medicine since 1994 and awarded Fellow of the American Academy of Family Physicians in 2001. He received the ‘Teacher of the Year’ award from the University of Kansas School of Medicine at completion of his residency in Family Medicine. He completed a fellowship at Wake Forest University in the field of vascular neurosonology. He holds a medical patent in the field of Gastroenterology. He holds an unrestricted license to practice medicine and surgery in Florida. He started his medical career as a Emergency Medical Technician, then as a Paramedic and later a Medical Doctor.